Detalhe da pesquisa
1.
Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension.
J Pharmacol Exp Ther
; 368(3): 462-473, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622171
2.
Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention.
J Pharmacol Exp Ther
; 361(2): 322-333, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223322
3.
Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low ß-Arrestin Recruitment and Desensitization Potential.
J Pharmacol Exp Ther
; 362(1): 186-199, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28476928
4.
A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.
Am J Respir Cell Mol Biol
; 52(2): 217-31, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25029475
5.
Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors.
J Cardiovasc Pharmacol
; 66(4): 332-7, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25992919
6.
Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension.
J Cardiovasc Pharmacol
; 66(5): 457-67, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26230396
7.
Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Bioorg Med Chem Lett
; 25(18): 3941-6, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26231163
8.
Macitentan does not interfere with hepatic bile salt transport.
J Pharmacol Exp Ther
; 350(1): 130-43, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24769543
9.
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
Nat Med
; 13(2): 150-5, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17259994
10.
Effective treatment of advanced Hodgkin lymphoma with a modified BEACOPP regimen for a patient with demyelinating hereditary motor and sensory neuropathy type 1 (HMSN1).
Clin Case Rep
; 10(5): e05766, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35540715
11.
The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.
J Pharmacol Exp Ther
; 337(2): 547-56, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21345969
12.
Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.
J Pharmacol Exp Ther
; 335(1): 249-55, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660124
13.
Design and optimization of new piperidines as renin inhibitors.
Bioorg Med Chem Lett
; 20(21): 6286-90, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843686
14.
Piperidine-based renin inhibitors: upper chain optimization.
Bioorg Med Chem Lett
; 20(21): 6291-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843690
15.
New classes of potent and bioavailable human renin inhibitors.
Bioorg Med Chem Lett
; 19(23): 6762-5, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19853442
16.
Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist.
J Pharmacol Exp Ther
; 327(3): 736-45, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18780830
17.
A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model.
PLoS One
; 13(3): e0193057, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29547661
18.
The reversible P2Y12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.
Pharmacol Res Perspect
; 5(5)2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28805949
19.
Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226621
20.
Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.
J Med Chem
; 60(9): 3776-3794, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28406300