Detalhe da pesquisa
1.
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell
; 187(10): 2536-2556.e30, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38653237
2.
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation.
Proc Natl Acad Sci U S A
; 118(17)2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33888587
3.
A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry.
J Biol Chem
; 295(12): 3783-3793, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32014998
4.
The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.
Nucleic Acids Res
; 45(6): 3591-3605, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082398
5.
Structure and mechanism of the ATPase that powers viral genome packaging.
Proc Natl Acad Sci U S A
; 112(29): E3792-9, 2015 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26150523
6.
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).
Bioorg Med Chem
; 24(12): 2707-15, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27156192
7.
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Cancer Discov
; 13(11): 2432-2447, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623743
8.
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
bioRxiv
; 2023 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961514
9.
Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing.
Nat Commun
; 13(1): 2833, 2022 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35595757
10.
A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.
Structure
; 26(7): 936-947.e3, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779790
11.
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Nat Commun
; 8: 15024, 2017 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28452355
12.
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Cell Rep
; 21(11): 3243-3255, 2017 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29241550
13.
A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J Mol Biol
; 428(6): 1023-1040, 2016 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26688547
14.
Structure-guided design of a high affinity inhibitor to human CtBP.
ACS Chem Biol
; 10(4): 1118-27, 2015 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25636004
15.
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
FEBS Lett
; 588(9): 1743-8, 2014 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24657618