Detalhe da pesquisa
1.
Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age.
BMC Womens Health
; 23(1): 236, 2023 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37149578
2.
Comprehensive folding variations for protein folding.
Proteins
; 90(11): 1851-1872, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35514069
3.
Discovery of novel spiro compound as RAF kinase inhibitor with in vitro potency against KRAS mutant cancer.
Bioorg Med Chem Lett
; 63: 128666, 2022 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35276360
4.
Using multiple isotopes to identify sources and transport of nitrate in urban residential stormwater runoff.
Environ Monit Assess
; 194(3): 238, 2022 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35235063
5.
Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.
Bioorg Med Chem
; 26(3): 581-589, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317148
6.
Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model.
Bioorg Med Chem Lett
; 26(2): 277-282, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704267
7.
WITHDRAWN: Discovery of SHR1977: A highly potent and selective ROMK inhibitor.
Bioorg Med Chem Lett
; 2016 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377326
8.
Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers.
Bioorg Med Chem Lett
; 26(3): 819-823, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26739779
9.
Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors.
Bioorg Med Chem Lett
; 24(11): 2555-9, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755426
10.
Discovery of novel orally bioavailable GPR40 agonists.
Bioorg Med Chem Lett
; 23(10): 2920-4, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23582779
11.
Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide.
Drug Metab Dispos
; 40(8): 1575-87, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22587988
12.
Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.
Eur J Med Chem
; 228: 114040, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34906761
13.
Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.
J Comput Aided Mol Des
; 25(7): 689-98, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21779981
14.
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.
J Comput Aided Mol Des
; 25(7): 621-36, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21604056
15.
A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer.
Onco Targets Ther
; 14: 4561-4574, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34466002
16.
Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis.
Sci Rep
; 11(1): 9132, 2021 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33911101
17.
Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors.
ACS Med Chem Lett
; 12(2): 195-201, 2021 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33603965
18.
Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity.
J Med Chem
; 64(20): 14983-14996, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34643383
19.
4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 20(20): 6096-9, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817449
20.
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK.
Bioorg Med Chem Lett
; 20(24): 7429-34, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21036042