Detalhe da pesquisa
1.
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc Natl Acad Sci U S A
; 121(6): e2317756121, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38300868
2.
Biomimetic Platinum-Promoted Polyene Polycyclizations: Influence of Alkene Substitution and Pre-cyclization Conformations.
J Am Chem Soc
; 139(32): 11158-11164, 2017 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28719198
3.
Enantioselective Diels-Alder-lactamization organocascades employing a furan-based diene.
Org Biomol Chem
; 15(15): 3179-3183, 2017 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28358148
4.
Mechanistic studies of copper(I)-catalyzed 1,3-halogen migration.
J Am Chem Soc
; 137(16): 5346-54, 2015 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25828031
5.
Acylammonium salts as dienophiles in Diels-Alder/lactonization organocascades.
J Am Chem Soc
; 136(12): 4492-5, 2014 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24588428
6.
ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.
Bioorg Med Chem Lett
; 24(24): 5840-5844, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452003
7.
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Cancer Discov
; 13(9): 2012-2031, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270847
8.
qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J Med Chem
; 61(24): 11183-11198, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30457858
9.
Stereodivergent, Diels-Alder-initiated organocascades employing α,ß-unsaturated acylammonium salts: scope, mechanism, and application.
Chem Sci
; 8(2): 1511-1524, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28616147
10.
Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking.
J Med Chem
; 57(15): 6729-38, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25061695