Detalhe da pesquisa
1.
Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties.
J Biol Chem
; 296: 100443, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33617882
2.
GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.
J Biol Chem
; 297(2): 100928, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274316
3.
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1.
SLAS Discov
; 28(1): 3-11, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36414185
4.
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
EMBO Mol Med
; 13(3): e13167, 2021 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33512066
5.
Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm.
Biochem J
; 419(1): 65-73, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19061480
6.
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
J Med Chem
; 63(6): 3348-3358, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32109056
7.
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.
JCI Insight
; 3(16)2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135318
8.
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J Med Chem
; 60(8): 3383-3404, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28398044
9.
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun
; 8: 15827, 2017 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28604669
10.
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Nat Med
; 22(2): 202-9, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26752518
11.
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-ß-d-ribose Oxidase.
ACS Infect Dis
; 1(12): 615-26, 2015 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27623058
12.
A modular, fully integrated ultra-high-throughput screening system based on confocal fluorescence analysis techniques.
J Biomol Screen
; 8(6): 648-59, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14711390
13.
Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometry.
J Biomol Screen
; 19(4): 508-15, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24381207
14.
Fluorescence-based assays.
Prog Med Chem
; 43: 19-48, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15850822