Detalhe da pesquisa
1.
Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.
Mol Pharmacol
; 96(2): 158-167, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31175181
2.
Prediction of Clinically Relevant Herb-Drug Clearance Interactions Using Sandwich-Cultured Human Hepatocytes: Schisandra spp. Case Study.
Drug Metab Dispos
; 45(9): 1019-1026, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28698304
3.
Contextualizing Hepatocyte Functionality of Cryopreserved HepaRG Cell Cultures.
Drug Metab Dispos
; 44(9): 1463-79, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27338863
4.
Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene.
Drug Metab Dispos
; 43(1): 93-9, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349122
5.
Early Drug-Induced Liver Injury Risk Screening: "Free," as Good as It Gets.
Toxicol Sci
; 188(2): 208-218, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35639956
6.
Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease.
Drug Metab Dispos
; 39(10): 1954-60, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21737566
7.
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Drug Metab Dispos
; 37(10): 2087-94, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19651758
8.
The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity.
Methods Mol Biol
; 1981: 75-85, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31016648
9.
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Drug Metab Dispos
; 36(8): 1716-21, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18474683
10.
Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.
Arch Toxicol
; 82(12): 959-64, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18488193
11.
Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).
Toxicol Sci
; 161(2): 401-411, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29069498
12.
Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich-cultured human hepatocytes.
Pharmacol Res Perspect
; 5(4)2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28805978
13.
Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226620
14.
In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes.
Chem Biol Interact
; 179(2-3): 263-72, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19135037
15.
Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.
Drug Metab Dispos
; 34(12): 2003-10, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16936065
16.
The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29.
Mol Pharmacol
; 65(6): 1397-404, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15155833