Detalhe da pesquisa
1.
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
Bioorg Med Chem Lett
; 23(3): 767-72, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265881
2.
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.
Bioorg Med Chem Lett
; 23(11): 3358-63, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23622982
3.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940470
4.
The flexible alignment of molecular structures using simulated annealing with weighted Lagrangian multipliers.
J Comput Chem
; 32(2): 210-7, 2011 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20662084
5.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356246
6.
Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Chem Res Toxicol
; 22(9): 1603-12, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19697924
7.
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
ACS Med Chem Lett
; 9(9): 872-877, 2018 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30258533
8.
Virtual screening: are we there yet?
Mini Rev Med Chem
; 6(10): 1159-67, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17073716
9.
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
J Med Chem
; 59(5): 2005-24, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756222
10.
QT interval prolongation: and the beat goes on.
Mini Rev Med Chem
; 5(12): 1083-91, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16375754
11.
Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy.
J Med Chem
; 47(1): 45-55, 2004 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14695819
12.
Prediction of drug-like molecular properties: modeling cytochrome p450 interactions.
Methods Mol Biol
; 275: 449-520, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15141126
13.
Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.
J Med Chem
; 55(18): 8091-109, 2012 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22924734
14.
Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
J Med Chem
; 54(12): 4219-33, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21557540
15.
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.
Bioorg Med Chem Lett
; 17(13): 3575-80, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17482464
16.
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Anal Biochem
; 360(1): 30-40, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17113558
17.
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.
Bioorg Med Chem
; 15(17): 5912-49, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17574423
18.
Ketopiperazine-based renin inhibitors: optimization of the "C" ring.
Bioorg Med Chem Lett
; 16(9): 2500-4, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16480874
19.
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.
Bioorg Med Chem Lett
; 15(9): 2371-4, 2005 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837327
20.
Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.
Bioorg Med Chem Lett
; 15(21): 4713-6, 2005 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16143527