Assuntos
Calcinose/complicações , Hipercalcemia/diagnóstico , Hiperparatireoidismo/diagnóstico por imagem , Cápsula do Cristalino/patologia , Transtornos da Visão/etiologia , Idoso de 80 Anos ou mais , Fosfatase Alcalina/sangue , Biópsia , Cálcio/sangue , Diagnóstico Diferencial , Feminino , Humanos , Hipercalcemia/complicações , Hiperparatireoidismo/complicações , Cápsula do Cristalino/cirurgia , Neoplasias das Paratireoides/complicações , Cintilografia , Resultado do Tratamento , Transtornos da Visão/diagnóstico , Transtornos da Visão/terapiaRESUMO
Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.
Assuntos
Canais de Cálcio Tipo P/genética , Canais de Cálcio Tipo Q/genética , Mutação , Animais , Canais de Cálcio Tipo N , Ataxia Cerebelar/genética , Cerebelo/fisiologia , Cerebelo/fisiopatologia , Fixação Ocular , Camundongos , Primatas , Transdução de SinaisRESUMO
Mice carrying mutations of the gene encoding the ion pore of the P/Q calcium channel (Cacna1a) are an instance in which cerebellar dysfunction may be attributable to altered electrophysiology and thus provide an opportunity to study how neuronal intrinsic properties dictate signal processing in the ocular motor system. P/Q channel mutations can engender multiple effects at the single neuron, circuit, and behavioral levels; correlating physiological and behavioral abnormalities in multiple allelic strains will ultimately facilitate determining which alterations of physiology are responsible for specific behavioral aberrations. We used videooculography to quantify ocular motor behavior in tottering mutants aged 3 mo to 2 yr and compared their performance to data previously obtained in the allelic mutant rocker and C57BL/6 controls. Tottering mutants shared numerous abnormalities with rocker, including upward deviation of the eyes at rest, increased vestibuloocular reflex (VOR) phase lead at low stimulus frequencies, reduced VOR gain at high stimulus frequencies, reduced gain of the horizontal and vertical optokinetic reflex, reduced time constants of the neural integrator, and reduced plasticity of the VOR as assessed in a cross-axis training paradigm. Unlike rocker, young tottering mutants exhibited normal peak velocities of nystagmus fast phases, arguing against a role for neuromuscular transmission defects in the attenuation of compensatory eye movements. Tottering also differed by exhibiting directional asymmetries of the gains of optokinetic reflexes. The data suggest at least four pathophysiological mechanisms (two congenital and two acquired) are required to explain the ocular motor deficits in the two Cacna1a mutant strains.
Assuntos
Envelhecimento/fisiologia , Canais de Cálcio Tipo P/metabolismo , Canais de Cálcio Tipo Q/metabolismo , Movimentos Oculares/fisiologia , Proteínas do Olho/metabolismo , Animais , Canais de Cálcio Tipo N , Canais de Cálcio Tipo P/deficiência , Canais de Cálcio Tipo P/genética , Canais de Cálcio Tipo Q/deficiência , Canais de Cálcio Tipo Q/genética , Proteínas do Olho/genética , Camundongos , Camundongos Endogâmicos C57BL , Mutação , Reflexo Vestíbulo-Ocular/fisiologiaRESUMO
OBJECTIVE: To review clinical presentation, management and outcomes following different therapies in patients with pituitary apoplexy. METHODS: Retrospective analysis of case-records of patients with classical pituitary apoplexy treated in our hospitals between 1983-2004. RESULTS: Forty-five patients (28 men; mean age 49 years, range 16-72 years) were identified. Only 8 (18%) were known to have pituitary adenomas at presentation. Thirty-four (81%) patients had hypopituitarism at presentation. CT and MRI identified pituitary apoplexy in 28% and 91% cases, respectively. Twenty-seven (60%) patients underwent surgical decompression, whilst 18 (40%) were managed conservatively. Median time from presentation to surgery was 6 days (range 1-121 days). Patients with visual field defects were more likely than those without these signs to be managed surgically (p = 0.01). Complete or near-complete resolution occurred in 93% (13/14), 94% (15/16) and 93% (13/14) of the surgically treated patients with reduced visual acuity, visual field deficit and ocular palsy, respectively. All patients with reduced visual acuity (4/4), visual field deficit (4/4) and ocular palsy (8/8) in the conservative group had complete or near-complete recovery. Only 5 (19%) patients in the surgical group and 2 (11%) in the conservative group had normal pituitary function at follow up. One (4%) patient in the surgical group and 4 (22%) in the conservative group had a recurrence of pituitary adenoma. CONCLUSIONS: This large series suggests that the patients with classical pituitary apoplexy, who are without neuro-ophthalmic signs or exhibit mild and non-progressive signs, can be managed conservatively in the acute stage.