Detalhe da pesquisa
1.
Genomic atlas of the human plasma proteome.
Nature
; 558(7708): 73-79, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29875488
2.
Modified nucleotides may have enhanced early RNA catalysis.
Proc Natl Acad Sci U S A
; 117(15): 8236-8242, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229566
3.
Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging.
Nat Methods
; 15(9): 685-688, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30127504
4.
Vascular dysfunction following breath-hold diving.
Can J Physiol Pharmacol
; 98(2): 124-130, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31505129
5.
Selection of DNA aptamers with two modified bases.
Proc Natl Acad Sci U S A
; 114(11): 2898-2903, 2017 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265062
6.
Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation.
Int J Mol Sci
; 21(8)2020 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32316583
7.
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers.
Biochemistry
; 58(46): 4632-4640, 2019 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31638376
8.
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
PLoS Med
; 16(4): e1002781, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30990820
9.
Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
PLoS Med
; 16(7): e1002880, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31318860
10.
Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685472
11.
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Proc Natl Acad Sci U S A
; 113(30): E4357-66, 2016 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357661
12.
Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28584140
13.
Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection.
J Clin Microbiol
; 55(2): 391-402, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27852671
14.
Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis.
J Clin Microbiol
; 55(10): 3057-3071, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28794177
15.
Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications.
J Clin Microbiol
; 55(10): 3072-3088, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28794178
16.
Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides.
Nucleic Acids Res
; 43(19): 9107-22, 2015 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438535
17.
Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.
J Biol Chem
; 289(12): 8706-19, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24415766
18.
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand.
J Biol Chem
; 289(12): 8720-34, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24415767
19.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc Natl Acad Sci U S A
; 109(49): 19971-6, 2012 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23139410
20.
Highly multiplexed proteomic platform for biomarker discovery, diagnostics, and therapeutics.
Adv Exp Med Biol
; 735: 283-300, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23402035