Detalhe da pesquisa
1.
Consideration of Fractional Distribution Parameter fd in the Chen and Gross Method for Tissue-to-Plasma Partition Coefficients: Comparison of Several Methods.
Pharm Res
; 39(3): 463-479, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35288804
2.
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Cell Mol Life Sci
; 78(1): 207-225, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32140747
3.
Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry.
Molecules
; 25(3)2020 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31991809
4.
Suppression of Canine ATP Binding Cassette ABCB1 in Madin-Darby Canine Kidney Type II Cells Unmasks Human ABCG2-Mediated Efflux of Olaparib.
J Pharmacol Exp Ther
; 368(1): 79-87, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30396915
5.
Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo.
Planta Med
; 85(9-10): 719-728, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31137047
6.
Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2-Mediated Interaction in Hepatic Transport.
Drug Metab Dispos
; 45(3): 246-259, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28069721
7.
A Complete Extension of Classical Hepatic Clearance Models Using Fractional Distribution Parameter fd in Physiologically Based Pharmacokinetics.
J Pharm Sci
; 113(1): 95-117, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37279835
8.
Theoretical Examination Seeking Tangible Physical Meanings of Slopes and Intercepts of Plasma Concentration-Time Relationships in Minimal Physiologically Based Pharmacokinetic Models.
AAPS J
; 25(1): 19, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36702940
9.
Cerebrospinal Fluid Pharmacokinetics of Nicardipine Following Intrathecal Administration in Subarachnoid Hemorrhage Patients.
medRxiv
; 2023 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37905152
10.
Determinants of Biological Half-Lives and Terminal Slopes in Physiologically Based Pharmacokinetic Systems: Assessment of Limiting Conditions.
AAPS J
; 24(5): 96, 2022 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36042121
11.
Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically Based Pharmacokinetic (PBPK) Models I: Theoretical Consideration of Bottom-Up Approach of Lumping Tissues in Whole-Body PBPK.
AAPS J
; 24(5): 90, 2022 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36002760
12.
Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically Based Pharmacokinetic (PBPK) Models II: Practical Application of Tissue Lumping Theories for Pharmacokinetics of Various Compounds.
AAPS J
; 24(5): 91, 2022 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36002779
13.
Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics.
Pharmaceutics
; 14(6)2022 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35745730
14.
Metronomic dose-finding approach in oral chemotherapy by experimentally-driven integrative mathematical modeling.
Biomaterials
; 286: 121584, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35617783
15.
Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species.
Pharmaceuticals (Basel)
; 14(6)2021 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34200427
16.
Effects of 1α,25-Dihydroxyvitamin D3 on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach.
Pharmaceutics
; 13(8)2021 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34452094
17.
Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans.
Pharmaceutics
; 13(6)2021 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34072547
18.
Investigation of the Factors Responsible for the Poor Oral Bioavailability of Acacetin in Rats: Physicochemical and Biopharmaceutical Aspects.
Pharmaceutics
; 13(2)2021 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33525442
19.
A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction.
Biochem Pharmacol
; 178: 114053, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32450253
20.
Carfilzomib Delivery by Quinic Acid-Conjugated Nanoparticles: Discrepancy Between Tumoral Drug Accumulation and Anticancer Efficacy in a Murine 4T1 Orthotopic Breast Cancer Model.
J Pharm Sci
; 109(4): 1615-1622, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31945310