Detalhe da pesquisa
1.
Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFß2 activation.
Development
; 150(9)2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37102682
2.
Defining the mechanism of galectin-3-mediated TGF-ß1 activation and its role in lung fibrosis.
J Biol Chem
; 300(6): 107300, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641066
3.
COVID-19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts.
Immunol Rev
; 302(1): 228-240, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34028807
4.
The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
Respir Res
; 24(1): 89, 2023 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36949463
5.
Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling.
Eur Respir J
; 60(1)2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34996828
6.
Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis.
Am J Respir Cell Mol Biol
; 58(5): 594-603, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29053339
7.
Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvß6 Expression.
J Biol Chem
; 291(18): 9540-53, 2016 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26861876
8.
Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis.
Lab Invest
; 96(6): 623-31, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26974397
9.
CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.
Am J Physiol Lung Cell Mol Physiol
; 308(9): L962-72, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25713319
10.
Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.
J Immunol
; 189(2): 819-31, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22689881
11.
Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function.
Pulm Pharmacol Ther
; 26(1): 75-85, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22800879
12.
Integrin αvß5-mediated TGF-ß activation by airway smooth muscle cells in asthma.
J Immunol
; 187(11): 6094-107, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22025551
13.
Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter.
J Immunol
; 183(7): 4682-92, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19734226
14.
Pharmacological characterisation of GSK3335103, an oral αvß6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease.
Eur J Pharmacol
; 913: 174618, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762934
15.
Loss of ELK1 has differential effects on age-dependent organ fibrosis.
Int J Biochem Cell Biol
; 120: 105668, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31877385
16.
Translational pharmacology of an inhaled small molecule αvß6 integrin inhibitor for idiopathic pulmonary fibrosis.
Nat Commun
; 11(1): 4659, 2020 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32938936
17.
The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization.
Mol Pharmacol
; 73(5): 1362-70, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18230715
18.
Methods for the Assessment of Active Transforming Growth Factor-ß in Cells and Tissues.
Methods Mol Biol
; 1627: 351-365, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28836213
19.
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.
Lancet Respir Med
; 5(11): 869-880, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29066090
20.
Amplification of TGFß Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.
PLoS One
; 11(8): e0158047, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27494713