Detalhe da pesquisa
1.
A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.
Mov Disord
; 31(7): 1049-54, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26990766
2.
A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.
Mov Disord
; 30(3): 427-31, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25689146
3.
Dose-dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492: Clear PK/PD relationship.
Epilepsia
; 56(6): 924-32, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25963722
4.
Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks.
Cephalalgia
; 34(2): 103-13, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23963355
5.
Dose titration of BAF312 attenuates the initial heart rate reducing effect in healthy subjects.
Br J Clin Pharmacol
; 75(3): 831-41, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22845008
6.
AFQ056 treatment of levodopa-induced dyskinesias: results of 2 randomized controlled trials.
Mov Disord
; 26(7): 1243-50, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21484867
7.
Efficacy and safety of single- and repeated-selurampanel dosing for 2 weeks in patients with chronic subjective tinnitus: Results of a randomized, double-blind, placebo-controlled, cross-over, proof-of-concept phase IIa study.
Prog Brain Res
; 260: 423-440, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33637230
8.
First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury.
Neurorehabil Neural Repair
; 32(6-7): 578-589, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29869587
9.
Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study.
Adv Ther
; 34(2): 524-541, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28044255
10.
Serum urate at trial entry and ALS progression in EMPOWER.
Amyotroph Lateral Scler Frontotemporal Degener
; 18(1-2): 120-125, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27677562
11.
Quantitative strength testing in ALS clinical trials.
Neurology
; 87(6): 617-24, 2016 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27385750
12.
Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study.
J Neurol
; 263(7): 1287-95, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27142710
13.
Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial.
Prog Neuropsychopharmacol Biol Psychiatry
; 71: 66-75, 2016 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27371157
14.
Somatic mitochondrial DNA mutations in single neurons and glia.
Neurobiol Aging
; 26(10): 1343-55, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16243605
15.
AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation.
Br J Pharmacol
; 172(5): 1292-304, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25363835
16.
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.
Neurobiol Aging
; 25(1): 71-81, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14675733
17.
Treatment of Leber's hereditary optic neuropathy: theory to practice.
Semin Ophthalmol
; 17(1): 33-8, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15513454
18.
The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in L-Dopa-treated parkinsonian monkeys.
Parkinsonism Relat Disord
; 17(4): 270-6, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315648
19.
Metabotropic glutamate receptor type 5 in levodopa-induced motor complications.
Neurobiol Aging
; 32(7): 1286-95, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20036444
20.
Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.
Sci Transl Med
; 3(64): 64ra1, 2011 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21209411