Enhancing the Accuracy of Non-Invasive Glucose Sensing in Aqueous Solutions Using Combined Millimeter Wave and Near Infrared Transmission.

We reported measurement results relating to non-invasive glucose sensing using a novel multiwavelength approach that combines radio frequency and near infrared signals in transmission through aqueous glucose-loaded solutions. Data were collected simultaneously in the 37-39 GHz and 900-1800 nm electromagnetic bands. We successfully detected changes in the glucose solutions with varying glucose concentrations between 80 and 5000 mg/dl. The measurements showed for the first time that, compared to single modality systems, greater accuracy on glucose level prediction can be achieved when combining transmission data from these distinct electromagnetic bands, boosted by machine learning algorithms.

Feasibility Study of Enhancing Microwave Brain Imaging Using Metamaterials.

We present an approach to enhance microwave brain imaging with an innovative metamaterial (MM) planar design based on a cross-shaped split-ring resonator (SRR-CS). The proposed metasurface is incorporated in different setups, and its interaction with EM waves is studied both experimentally and by using CST Microwave Studio® and is compared to a "no MM" case scenario. We show that the MM can enhance the penetration of the transmitted signals into the human head when placed in contact with skin tissue, acting as an impedance-matching layer. In addition, we show that the MM can improve the transceivers' ability to detect useful "weak" signals when incorporated in a headband scanner for brain imaging by increasing the signal difference from a blood-like dielectric target introduced into the brain volume. Our results suggest that the proposed MM film can be a powerful hardware advance towards the development of scanners for brain haemorrhage detection and monitoring.

Design and Experimental Validation of a Multiple-Frequency Microwave Tomography System Employing the DBIM-TwIST Algorithm.

We present a first prototype of a wideband microwave tomography system with potential application to medical imaging. The system relies on a compact and robust printed monopole antenna which can operate in the 1.0⁻3.0 GHz range when fully immersed in commonly used coupling liquids, such as glycerine⁻water solutions. By simulating the proposed imaging setup in CST Microwave Studio, we study the signal transmission levels and array sensitivity for different target and coupling liquid media. We then present the experimental prototype design and data acquisition process, and show good agreement between experimentally measured data and results from the CST simulations. We assess imaging performance by applying our previously proposed two-dimensional (2-D) DBIM TwIST-algorithm to both simulated and experimental datasets, and demonstrate that the system can reconstruct simple cylindrical targets at multiple frequencies.

Metasurface-Enhanced Antennas for Microwave Brain Imaging.

Stroke is a very frequent disorder and one of the major leading causes of death and disability worldwide. Timely detection of stroke is essential in order to select and perform the correct treatment strategy. Thus, the use of an efficient imaging method for an early diagnosis of this syndrome could result in an increased survival's rate. Nowadays, microwave imaging (MWI) for brain stroke detection and classification has attracted growing interest due to its non-invasive and non-ionising properties. In this paper, we present a feasibility study with the goal of enhancing MWI for stroke detection using metasurface (MTS) loaded antennas. In particular, three MTS-enhanced antennas integrated in different brain scanners are presented. For the first two antennas, which operate in a coupling medium, we show experimental measurements on an elliptical brain-mimicking gel phantom including cylindrical targets representing the bleeding in haemorrhagic stroke (h-stroke) and the not oxygenated tissue in ischaemic stroke (i-stroke). The reconstructed images and transmission and reflection parameter plots show that the MTS loadings improve the performance of our imaging prototype. Specifically, the signal transmitted across our head model is indeed increased by several dB's over the desired frequency range of 0.5-2.0 GHz, and an improvement in the quality of the reconstructed images is shown when the MTS is incorporated in the system. We also present a detailed simulation study on the performance of a new printed square monopole antenna (PSMA) operating in air, enhanced by a MTS superstrate loading. In particular, our previous developed brain scanner operating in an infinite lossy matching medium is compared to two tomographic systems operating in air: an 8-PSMA system and an 8-MTS-enhanced PSMA system. Our results show that our MTS superstrate enhances the antennas' return loss by around 5 dB and increases the signal difference due to the presence of a blood-mimicking target up to 25 dB, which leads to more accurate reconstructions. In conclusion, MTS structures may be a significant hardware advancement towards the development of functional and ergonomic MWI scanners for stroke detection.

A smart switching system to enable automatic tuning and detuning of metamaterial resonators in MRI scans.

We present a radio-frequency-activated switching system that can automatically detune a metamaterial resonator to enhance magnetic resonance imaging (MRI) performance. Local sensitivity-enhancing metamaterials typically consist of resonant components, which means that the transmitted radio frequency field is spatially inhomogeneous. The switching system shows for the first time that a metamaterial resonator can be detuned during transmission and tuned during reception using a digital circuit. This allows a resonating system to maintain homogeneous transmit field while maintaining an increased receive sensitivity. As a result, sensitivity can be enhanced without changing the system-provided specific absorption rate (SAR) models. The developed digital circuit consists of inductors sensitive to the transmit radio-frequency pulses, along with diodes acting as switches to control the resonance frequency of the resonator. We first test the automatic resonator detuning on-the-bench, and subsequently evaluate it in a 1.5 T MRI scanner using tissue-mimicking phantoms. The scan results demonstrate that the switching mechanism automatically detunes the resonator in transmit mode, while retaining its sensitivity-enhancing properties (tuned to the Larmor frequency) in receive mode. Since it does not require any connection to the MRI console, the switching system can have broad applications and could be adapted for use with other types of MRI scanners and field-enhancing resonators.

Manipulating the loss in electromagnetic cloaks for perfect wave absorption.

We examine several ways to manipulate the loss in electro-magnetic cloaks, based on transformation electromagnetics. It is found that, by utilizing inherent electric and magnetic losses of metamaterials, perfect wave absorption can be achieved based on several popular designs of electromagnetic cloaks. A practical implementation of the absorber, consisting of ten discrete layers of metamaterials, is proposed. The new devices demonstrate super-absorptivity over a moderate wideband range, suitable for both microwave and optical applications. It is corroborated that the device is functional with a subwavelength thickness and, hence, advantageous compared to the conventional absorbers.

Metasurface Resonator for 1.5 T MRI Based on BaTiO3 Host Material.

Magnetic resonance imaging (MRI) is a widely used clinical tool for medical diagnosis and therapy. Several research studies focus on passively improving MRI sensitivity using high dielectric constant (HDC) materials and metamaterials. In this work, we investigate a new metasurface resonator which can enhance local transmit and receive efficiency in 1.5T MRI. The metasurface has been realized with an array of non-magnetic rods embedded in two blocks of a BaTiO3 aqueous mixture. BaTiO3 when mixed with water exhibits high dielectric permittivity values in the 40-200 MHz range, allowing the design of a compact and safe device for practical use in an MRI scanner. Simulation results show 50% enhancement of the magnetic field in the region-of-interest. The resonance frequency of the metasurface is also validated experimentally with a small loop antenna and a vector network analyzer (VNA) in a laboratory-controlled environment.

Dielectric permittivity of human blood of different lactate levels measured at millimeter waves.

The investigation of variations in dielectric properties of blood based on its biochemical profile is important for determining the feasibility of developing electromagnetic non-invasive sensing systems for monitoring the levels of various metabolites in blood. In this paper, the real and imaginary parts of dielectric permittivity are measured as a function of lactate concentration in the 30-60 GHz frequency range using two different measurement techniques. The blood samples are collected from a healthy subject undergoing three different exercise modes and the dielectric properties are measured with an open-ended coaxial probe technique and a custom-made millimeter wave transmission system. Good correlation is observed in measurements from the two methods, suggesting that an increase in lactate concentration lowers the imaginary part of permittivity and thus causing higher attenuation.

Feasibility Experiments to Detect Skin Hydration Using a Bio-Impedance Sensor.

We present proof of concept experiment of a sensing method to detect skin hydration using a low-cost bio-impedance sensor. The sensing system is validated by testing its current output over frequencies between 1 kHz and 50 kHz and comparing measured values of impedance. A series of experiments with salt-water mixtures as well as a gelatin-based phantom were carried out to test the sensor's ability to detect small changes in impedance due to changes in water content. We also compared impedance measurements from the phantom to human skin to confirm that the manufactured phantoms can mimic skin properties successfully. Our experimental results show that the sensor can detect small changes in salt concentration and can capture the correlation between the impedance and skin hydration in a reliable manner.

Experimental investigation of a metasurface resonator for in vivo imaging at 1.5 T.

In this work, we experimentally demonstrate an increase in the local transmit efficiency of a 1.5 T MRI scanner by using a metasurface formed by an array of brass wires embedded in a high permittivity low loss medium. Placement of such a structure inside the scanner results in strong coupling of the radiofrequency field produced by the body coil with the lowest frequency electromagnetic eigenmode of the metasurface. This leads to spatial redistribution of the near fields with enhancement of the local magnetic field and an increase in the transmit efficiency per square root maximum specific absorption rate in the region-of-interest. We have investigated this structure in vivo and achieved a factor of 3.3 enhancement in the local radiofrequency transmit efficiency.

A Glucose Sensing System Based on Transmission Measurements at Millimetre Waves using Micro strip Patch Antennas.

We present a sensing system operating at millimetre (mm) waves in transmission mode that can measure glucose level changes based on the complex permittivity changes across the signal path. The permittivity of a sample can change significantly as the concentration of one of its substances varies: for example, blood permittivity depends on the blood glucose levels. The proposed sensing system uses two facing microstrip patch antennas operating at 60 GHz, which are placed across interrogated samples. The measured transmission coefficient depends on the permittivity change along the signal path, which can be correlated to the change in concentration of a substance. Along with theoretical estimations, we experimentally demonstrate the sensing performance of the system using controlled laboratory samples, such as water-based glucose-loaded liquid samples. We also present results of successful glucose spike detection in humans during an in-vivo Intravenous Glucose Tolerance Test (IVGTT). The system could eventually be developed into a non-invasive glucose monitor for continuous monitoring of glucose levels for people living with diabetes, as it can detect as small as 1.33 mmol/l (0.025 wt%) glucose concentrations in the controlled water-based samples satisfactorily, which is well below the typical human glucose levels of 4 mmol/l.

Dispersive cylindrical cloaks under nonmonochromatic illumination.

Transformation-based cylindrical cloaks and concentrators are illuminated with nonmonochromatic waves and unusual effects are observed with interesting potential applications. The transient responses of the devices are studied numerically with the finite-difference time-domain method and the results are verified with analytical formulas. We compute the effective bandwidth of several cloaking schemes as well as the effect of losses on the performance of the structures. We also find that narrowband behavior, frequency shift effects, time delays, and spatial disturbances of the incoming waves are dominant due to the inherently dispersive nature of the devices. These effects are important and should be taken into account when designing metamaterial-based devices.

High-gradient plasma-wakefield acceleration with two subpicosecond electron bunches.

A plasma-wakefield experiment is presented where two 60 MeV subpicosecond electron bunches are sent into a plasma produced by a capillary discharge. Both bunches are shorter than the plasma wavelength, and the phase of the second bunch relative to the plasma wave is adjusted by tuning the plasma density. It is shown that the second bunch experiences a 150 MeV/m loaded accelerating gradient in the wakefield driven by the first bunch. This is the first experiment to directly demonstrate high-gradient, controlled acceleration of a short-pulse trailing electron bunch in a high-density plasma.