Detalhe da pesquisa
1.
Allogeneic chimeric antigen receptor-T cells with CRISPR-disrupted programmed death-1 checkpoint exhibit enhanced functional fitness.
Cytotherapy
; 25(7): 750-762, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37086241
2.
Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses.
Nucleic Acids Res
; 45(3): 1469-1478, 2017 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28180327
3.
Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2).
Bioorg Med Chem Lett
; 24(2): 515-9, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374270
4.
High-Specificity CRISPR-Mediated Genome Engineering in Anti-BCMA Allogeneic CAR T Cells Suppresses Allograft Rejection in Preclinical Models.
Cancer Immunol Res
; 12(4): 462-477, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38345397
5.
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas.
CRISPR J
; 7(1): 12-28, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38353617
6.
Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors.
Bioorg Med Chem Lett
; 23(14): 4072-5, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23756368
7.
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Bioorg Med Chem Lett
; 23(2): 569-73, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23232060
8.
HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans.
Clin Cancer Res
; 28(24): 5405-5418, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36190432
9.
Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease.
JCI Insight
; 5(12)2020 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32379724
10.
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo.
Cancer Res
; 67(12): 5798-805, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17575147
11.
Harnessing type I CRISPR-Cas systems for genome engineering in human cells.
Nat Biotechnol
; 37(12): 1471-1477, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31740839
12.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18072718
13.
HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma.
Mol Cancer Ther
; 17(1): 140-149, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29079709
14.
RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg.
Sci Transl Med
; 9(409)2017 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954926
15.
Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.
ACS Med Chem Lett
; 6(1): 63-7, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25589932
16.
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
J Med Chem
; 47(18): 4517-29, 2004 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15317463
17.
A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas.
Neoplasia
; 16(5): 403-12, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24953177
18.
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
Mol Cancer Ther
; 12(8): 1453-60, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23720766
19.
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Clin Cancer Res
; 19(1): 279-90, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23091115
20.
Epigenetic drug discovery: targeting DNA methyltransferases.
J Biomol Screen
; 17(1): 2-17, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21965114