Detalhe da pesquisa
1.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Proc Natl Acad Sci U S A
; 116(33): 16420-16429, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31371506
2.
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Bioorg Med Chem Lett
; 28(1): 15-23, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29169673
3.
Innovations and Challenges of Implementing a Glucose Gel Toolkit for Neonatal Hypoglycemia.
Adv Neonatal Care
; 18(5): 378-385, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29846198
4.
Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.
Bioorg Med Chem Lett
; 27(23): 5221-5224, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29107542
5.
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Bioorg Med Chem Lett
; 26(3): 742-746, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26774655
6.
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.
J Med Chem
; 67(11): 8708-8729, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38748820
7.
Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats.
Exp Physiol
; 98(1): 109-22, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22750422
8.
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Bioorg Med Chem Lett
; 23(16): 4652-6, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23820386
9.
Splenic neurohormonal modulation of mesenteric vascular tone.
Exp Physiol
; 97(9): 1054-64, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22198012
10.
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.
Bioorg Med Chem Lett
; 21(13): 3951-6, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21641217
11.
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer.
Cancer Cell
; 39(7): 928-944.e6, 2021 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33961783
12.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
J Med Chem
; 64(5): 2534-2575, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596065
13.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
J Med Chem
; 64(5): 2576-2607, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596073
14.
Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.
Bioorg Med Chem Lett
; 20(23): 6895-8, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035331
15.
Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib.
Bioorg Med Chem
; 18(19): 6977-86, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817538
16.
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
Nat Commun
; 11(1): 6387, 2020 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318494
17.
Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity.
ACS Med Chem Lett
; 11(12): 2389-2396, 2020 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335661
18.
Antibody Conjugation of a Chimeric BET Degrader Enables inâ vivo Activity.
ChemMedChem
; 15(1): 17-25, 2020 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31674143
19.
Adrenomedullin-induced dilation of human placental arteries is modulated by an endothelium-derived constricting factor.
Regul Pept
; 146(1-3): 183-8, 2008 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17936374
20.
Spermicidal bacteriocins: lacticin 3147 and subtilosin A.
Bioorg Med Chem Lett
; 18(10): 3103-6, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18042385