Detalhe da pesquisa
1.
Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial.
Blood
; 142(14): 1208-1218, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37366170
2.
First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers.
Mov Disord
; 32(2): 211-218, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27886407
3.
The mechanism of action, pharmacological characteristics, and clinical utility of the amyloid depleter birtamimab for the potential treatment of AL amyloidosis.
Leuk Lymphoma
; : 1-11, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38600883
4.
Neutralization of soluble, synaptotoxic amyloid ß species by antibodies is epitope specific.
J Neurosci
; 32(8): 2696-702, 2012 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357853
5.
Vascular alterations in PDAPP mice after anti-Aß immunotherapy: Implications for amyloid-related imaging abnormalities.
Alzheimers Dement
; 9(5 Suppl): S105-15, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583235
6.
Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
J Neurosci
; 30(19): 6743-50, 2010 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20463236
7.
Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.
J Biol Chem
; 285(10): 7619-32, 2010 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20032460
8.
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Front Neurol
; 12: 705407, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34659081
9.
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1488-91, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179073
10.
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(5): 1492-5, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181525
11.
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.
JAMA Neurol
; 75(10): 1206-1214, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29913017
12.
The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.
Curr Top Med Chem
; 6(6): 597-608, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16712494
13.
Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.
Curr Top Med Chem
; 6(8): 771-85, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16719816
14.
Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment.
Pharmacol Biochem Behav
; 84(1): 158-61, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16757017
15.
Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin.
Amyloid
; 23(2): 86-97, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26981744
16.
First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction.
J Clin Oncol
; 34(10): 1097-103, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858336
17.
2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis .
Amyloid
; 23(3): 168-177, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27494229
18.
The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.
J Neurosci
; 23(20): 7586-91, 2003 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12930797
19.
Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.
J Neurosci
; 23(18): 7218-26, 2003 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12904482
20.
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
J Med Chem
; 47(24): 5825-8, 2004 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15537338