Detalhe da pesquisa
1.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Nature
; 583(7816): 459-468, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32353859
2.
Reversible ADP-ribosylation of RNA.
Nucleic Acids Res
; 47(11): 5658-5669, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31216043
3.
ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication.
Proc Natl Acad Sci U S A
; 115(44): E10457-E10466, 2018 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30322911
4.
Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.
Curr Top Microbiol Immunol
; 420: 211-231, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242511
5.
Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor.
Chem Sci
; 13(46): 13898-13906, 2022 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36544740
6.
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Cell Chem Biol
; 29(12): 1694-1708.e10, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36493759
7.
Rational design of selective inhibitors of PARP4.
RSC Med Chem
; 12(11): 1950-1957, 2021 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34825190
8.
PASTA: PARP activity screening and inhibitor testing assay.
STAR Protoc
; 2(1): 100344, 2021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33665624
9.
Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
Elife
; 102021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33475084
10.
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
bioRxiv
; 2021 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501437
11.
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv
; 2020 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32511329
12.
Rational Design of Cell-Active Inhibitors of PARP10.
ACS Med Chem Lett
; 10(1): 74-79, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655950
13.
A Simple, Sensitive, and Generalizable Plate Assay for Screening PARP Inhibitors.
Methods Mol Biol
; 1813: 245-252, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30097873
14.
A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.
Cell Chem Biol
; 25(12): 1547-1553.e12, 2018 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344052
15.
A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.
mBio
; 8(3)2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28465426