Detalhe da pesquisa
1.
Incorporation of Intracellular NanoSIMS Tracers to Oligonucleotide Conjugates via Strain Promoted Sydnone-Alkyne Cycloaddition.
Bioconjug Chem
; 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38860868
2.
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.
J Am Chem Soc
; 143(9): 3416-3429, 2021 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33626278
3.
Synthesis of Diverse α-Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated Macrocycles.
Chemistry
; 25(5): 1184-1187, 2019 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30329185
4.
Late-Stage Functionalization of Histidine in Unprotected Peptides.
Angew Chem Int Ed Engl
; 58(52): 19096-19102, 2019 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31609503
5.
Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Typeâ II Diabetes.
Chemistry
; 24(12): 2832-2836, 2018 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211300
6.
Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.
Bioorg Med Chem Lett
; 24(3): 821-7, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24418773
7.
Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.
Bioorg Med Chem Lett
; 24(22): 5251-5, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25316315
8.
Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.
Angew Chem Int Ed Engl
; 53(16): 4056-75, 2014 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24470316
9.
Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.
Bioorg Med Chem Lett
; 23(1): 119-24, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200256
10.
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.
Cell Chem Biol
; 29(2): 300-311.e10, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320373
11.
Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists.
J Med Chem
; 65(19): 12956-12969, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36167503
12.
Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.
Bioorg Med Chem Lett
; 21(18): 5557-61, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782423
13.
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.
J Med Chem
; 64(14): 9906-9915, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34197114
14.
Target-Directed Approaches for Screening Small Molecules against RNA Targets.
SLAS Discov
; 25(8): 869-894, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32419578
15.
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions.
Nat Chem
; 12(10): 952-961, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32839603
16.
IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate.
PLoS One
; 14(8): e0220627, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31369634
17.
Stereocontrolled Synthesis of Tetrafluoropentanols: Multivicinal Fluorinated Alkane Units for Drug Discovery.
Org Lett
; 21(19): 7741-7745, 2019 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31398048
18.
Imidazopyridines as VLA-4 integrin antagonists.
Bioorg Med Chem Lett
; 18(14): 4146-9, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18539454
19.
Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosis.
Chem Commun (Camb)
; 54(85): 12002-12005, 2018 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30221278
20.
The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?
J Alzheimers Dis
; 64(s1): S547-S554, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29758944