Detalhe da pesquisa
1.
Structural Insights of a cis-Epoxysuccinate Hydrolase Facilitate the Development of Robust Biocatalysts for the Production of l-(+)-Tartrate.
Biochemistry
; 63(12): 1578-1587, 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38803051
2.
Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines.
Angew Chem Int Ed Engl
; 62(25): e202304994, 2023 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37083030
3.
Towards the Development of Orally Available Peptide Therapeutics.
Chimia (Aarau)
; 75(6): 514-517, 2021 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233815
4.
Interlaboratory analysis of teicoplanin plasma concentration assays among Chinese laboratories.
J Clin Pharm Ther
; 45(5): 983-990, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31985852
5.
Engineered Peptide Macrocycles Can Inhibit Matrix Metalloproteinases with High Selectivity.
Angew Chem Int Ed Engl
; 58(34): 11801-11805, 2019 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31251434
6.
Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J Am Chem Soc
; 140(1): 310-318, 2018 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29232125
7.
Phage Selection of Cyclic Peptides for Application in Research and Drug Development.
Acc Chem Res
; 50(8): 1866-1874, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28719188
8.
Protein engineering of aldolase LbDERA for enhanced activity toward real substrates with a high-throughput screening method coupled with an aldehyde dehydrogenase.
Biochem Biophys Res Commun
; 482(1): 159-163, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27833014
9.
Engineering Streptomyces coelicolor Carbonyl Reductase for Efficient Atorvastatin Precursor Synthesis.
Appl Environ Microbiol
; 83(12)2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28389544
10.
Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates.
Proc Natl Acad Sci U S A
; 111(44): 15717-22, 2014 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25331869
11.
Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution.
Angew Chem Int Ed Engl
; 54(42): 12410-5, 2015 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25891639
12.
Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition.
Biochem Biophys Res Commun
; 446(4): 1145-50, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24680822
13.
Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp.
Biotechnol Bioeng
; 111(10): 1920-30, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24771278
14.
Heterologous overexpression of Vigna radiata epoxide hydrolase in Escherichia coli and its catalytic performance in enantioconvergent hydrolysis of p-nitrostyrene oxide into (R)-p-nitrophenyl glycol.
Appl Microbiol Biotechnol
; 98(1): 207-18, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23615737
15.
A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-ß-blocker precursors.
Angew Chem Int Ed Engl
; 53(26): 6641-4, 2014 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841567
16.
Selection of Peptide-Bismuth Bicycles Using Phage Display.
ACS Chem Biol
; 19(5): 1040-1044, 2024 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38620022
17.
Engineered Glycosidase for Significantly Improved Production of Naturally Rare Vina-Ginsenoside R7.
J Agric Food Chem
; 71(8): 3852-3861, 2023 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36790033
18.
Generation of a 100-billion cyclic peptide phage display library having a high skeletal diversity.
Protein Eng Des Sel
; 342021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34341825
19.
A minimalistic cyclic ice-binding peptide from phage display.
Nat Commun
; 12(1): 2675, 2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33976148
20.
Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation.
J Med Chem
; 64(10): 6802-6813, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33974422