Minimal energetic expenditure of women walking burdened on gradients in urban environments.

OBJECTIVES: The objective is to understand the walking energy expenditure of women in urban environments (i.e., over-ground), using mass, velocity, gradient (incline and decline), and burden as predictors. In addition, we use an equation to determine the gradient associated with the minimum energy expenditure of walking. METHODS: To do this, we assessed the volumetric consumption of oxygen (VO2 ) of ten females (ages: 22-40 years) with a portable Cosmed K4b2 device. Participants walked at three self-selected, over-ground velocities (slow, normal, and fast) on five gradients (0%, +/-7.5%, +/- 12.4%) in different urban community settings burdened (10 kg) and unburdened. We performed a multilinear regression controlling for repeated measures to determine the best predictive equation for VO2 . The first derivative of our equation was used to find the gradient for minimal VO2 . RESULTS: Our equation explains 79% of the variation in VO2 and indicates that over-ground walking is similar to treadmill walking, except that the gradient associated with the minimal energy expenditure of walking is steeper (-11% to -20%) than that established from treadmill walking. CONCLUSIONS: Although our overall equation is an accurate predictor of VO2 for all velocities, burden, incline, and decline in this group, further research needs to be conducted to examine kinetic, kinematic, and velocity interactions in over-ground walking.

Morphological and postural sexual dimorphism of the lumbar spine facilitates greater lordosis in females.

Previous work suggests females are evolutionarily adapted to have greater lumbar lordosis than males to aid in pregnancy load-bearing, but no consensus exists. To explore further sex-differences in the lumbar spine, and to understand contradictions in the literature, we conducted a cross-sectional retrospective study of sex-differences in lumbar spine morphology and sacral orientation. In addition, our sample includes data for separate standing and supine samples of males and females to examine potential sex-differences in postural loading on lumbosacral morphology. We measured sagittal lumbosacral morphology on 200 radiographs. Measurements include: lumbar angle (L1-S1), lumbar vertebral body and disc wedging angles, sacral slope and pelvic incidence. Lumbar angle, representative of lordotic curvature between L1 and S1, was 7.3° greater in females than males, when standing. There were no significant sex-differences in lumbar angle when supine. This difference in standing lumbar angle can be explained by greater lordotic wedging of the lumbar vertebrae (L1-L5) in females. Additionally, sacral slope was greater in females than males, when standing. There were no significant sex-differences in pelvic incidence. Our results support that females have greater lumbar lordosis than males when standing, but not when supine - suggesting a potentially greater range of motion in the female spine. Furthermore, sex-differences in the lumbar spine appear to be supported by postural differences in sacral-orientation and morphological differences in the vertebral body wedging. A better understanding of sex-differences in lumbosacral morphology may explain sex-differences in spinal conditions, as well as promote necessary sex-specific treatments.

Brief communication: Lumbar lordosis in extinct hominins: implications of the pelvic incidence.

Recently, interest has peaked regarding the posture of extinct hominins. Here, we present a new method of reconstructing lordosis angles of extinct hominin specimens based on pelvic morphology, more specifically the orientation of the sacrum in relation to the acetabulum (pelvic incidence). Two regression models based on the correlation between pelvic incidence and lordosis angle in living hominoids have been developed. The mean values of the calculated lordosis angles based on these models are 36°-45° for australopithecines, 45°-47° for Homo erectus, 27°-34° for the Neandertals and the Sima de los Huesos hominins, and 49°-51° for fossil H. sapiens. The newly calculated lordosis values are consistent with previously published values of extinct hominins (Been et al.: Am J Phys Anthropol 147 (2012) 64-77). If the mean values of the present nonhuman hominoids are representative of the pelvic and lumbar morphology of the last common ancestor between humans and nonhuman hominoids, then both pelvic incidence and lordosis angle dramatically increased during hominin evolution from 27° ± 5 to 22° ± 3 (respectively) in nonhuman hominoids to 54° ± 10 and 51° ± 11 in modern humans. This change to a more human-like configuration appeared early in the hominin evolution as the pelvis and spines of both australopithecines and H. erectus show a higher pelvic incidence and lordosis angle than nonhuman hominoids. The Sima de los Huesos hominins and Neandertals show a derived configuration with a low pelvic incidence and lordosis angle.

Lumbar lordosis of extinct hominins.

The lordotic curvature of the lumbar spine (lumbar lordosis) in humans is a critical component in the ability to achieve upright posture and bipedal gait. Only general estimates of the lordotic angle (LA) of extinct hominins are currently available, most of which are based on the wedging of the vertebral bodies. Recently, a new method for calculating the LA in skeletal material has become available. This method is based on the relationship between the lordotic curvature and the orientation of the inferior articular processes relative to vertebral bodies in the lumbar spines of living primates. Using this relationship, we developed new regression models in order to calculate the LAs in hominins. The new models are based on primate group-means and were used to calculate the LAs in the spines of eight extinct hominins. The results were also compared with the LAs of modern humans and modern nonhuman apes. The lordotic angles of australopithecines (41° ± 4), H. erectus (45°) and fossil H. sapiens (54° ± 14) are similar to those of modern humans (51° ± 11). This analysis confirms the assumption that human-like lordotic curvature was a morphological change that took place during the acquisition of erect posture and bipedalism as the habitual form of locomotion. Neandertals have smaller lordotic angles (LA = 29° ± 4) than modern humans, but higher angles than nonhuman apes (22° ± 3). This suggests possible subtle differences in Neandertal posture and locomotion from that of modern humans.

Effect of standing and sitting positions on energy expenditure in people with transtibial amputation compared to age- and sex-matched controls.

BACKGROUND: Energy expenditure (EE) is often greater in people with lower-limb amputation, compared with healthy controls, because of the biomechanical compensations needed to walk with a prosthesis. Compensatory movements are required to stand with a prosthesis; however, little is known about whether standing with a prosthesis also requires greater EE. OBJECTIVE: The goal of this study was to examine the effect of standing and sitting positions on EE in people with transtibial amputation and matched controls. STUDY DESIGN: This is a secondary analysis. METHODS: Energy expenditure data from people with unilateral, transtibial amputation because of nondysvascular causes were compared with data from age- and sex-matched controls without amputation. Energy expenditure was defined as the mean volumetric rate of oxygen consumed over the last 2 of 5 minutes in each position and measured with a portable breath-by-breath metabolic analyzer. Repeated-measures analysis of variance was used to examine the effects of position (sitting and standing) and group (amputation and control) on EE. RESULTS: A significant interaction effect indicated participants with amputation showed a significantly greater increase in standing EE relative to sitting EE (26.2%) than did controls (13.4%). Simple main effects showed EE in standing was significantly greater than EE in sitting for both groups, but there were no significant differences in EE between groups during sitting or standing. CONCLUSIONS: Energy expenditure in standing, when measured relative to EE in sitting, is significantly greater in people with amputation. This result indicates that additional energy may be required to maintain an upright position with a lower-limb prosthesis.

Vertebral bodies or discs: which contributes more to human-like lumbar lordosis?

BACKGROUND: The attainment of upright posture, with its requisite lumbar lordosis, was a major turning point in human evolution. Nonhuman primates have small lordosis angles, whereas the human spine exhibits distinct lumbar lordosis (30 degrees -80 degrees ). We assume the lumbar spine of the pronograde ancestors of modern humans was like those of extant nonhuman primates, but which spinal components changed in the transition from small lordosis angles to large ones is not fully understood. QUESTIONS/PURPOSES: We wished to determine the relative contribution of vertebral bodies and intervertebral discs to lordosis angles in extant primates and humans. METHODS: We measured the lordosis, intervertebral disc, and vertebral body angles of 100 modern humans (orthograde primates) and 56 macaques (pronograde primates) on lateral radiographs of the lumbar spine (humans-standing, macaques-side-lying). RESULTS: The humans exhibited larger lordosis angles (51 degrees ) and vertebral body wedging (5 degrees ) than did the macaques (15 degrees and -25 degrees , respectively). The differences in wedging of the intervertebral discs, however, were much less pronounced (46 degrees versus 40 degrees ). CONCLUSIONS: These observations suggest the transition from pronograde to orthograde posture (ie, the lordosis angle) resulted mainly from an increase in vertebral body wedging and only in small part from the increase in wedging of the intervertebral discs.

The Effect of Parity on Age-Related Degenerative Changes in Sagittal Balance.

STUDY DESIGN: Retrospective cohort study. OBJECTIVE: Evaluate the effects of parity (number of births) on measures of sagittal posture in elderly women. The long-term objective of this study is to identify and mitigate factors contributing to age-related postural deformity in older adults. SUMMARY OF BACKGROUND DATA: Adult spinal deformity is a prevalent condition that often requires costly surgical management. Females are disproportionately represented in spinal deformity surgical cases with up to 90% of patients being women. The potential contributions of pregnancy on postural degeneration have only begun to be acknowledged and require further study. METHODS: Two hundred eight women with standing lateral radiographs were selected from the TwinsUK register. Parity information was extracted from questionnaires. Sagittal balance measurements (thoracic kyphosis, lumbar lordosis [LL], pelvic incidence [PI]) were collected and PI-LL mismatch was calculated. One-way analysis of variance tests were done between three separate age categories for measures of sagittal balance and parity and stepwise multivariate regression was done for PI-LL. RESULTS: Both age and PI-LL mismatch significantly differed between parity categories. PI-LL was on average 7.0°â€Š±â€Š2.5° greater in multiparous (3+ births) subjects than in nulliparous subjects (P < 0.01). Parity did not have an independent relationship with lumbar disc degeneration, lumbar bone mineral density, or any of the individual sagittal balance parameters (P > 0.05 for all), except for PI-LL. From a subanalysis of the effect of parity on sagittal alignment within twin pairs, we found that within pair differences in parity associate with within pair differences in thoracic kyphosis. CONCLUSION: This study established correlations between measures of spinal curvature in older women and parity for the first time. Longitudinal research is required to establish a causative relationship. LEVEL OF EVIDENCE: 4.

Development of Pelvic Incidence and Lumbar Lordosis in Children and Adolescents.

Pelvic incidence (PI) is a measure of the sagittal orientation of the sacrum relative to the acetabula and is not dependent on posture. In asymptomatic adults, PI correlates with lumbar lordosis. Lumbar lordosis is shown to increase with age following the onset of unassisted bipedal locomotion in children, but to what extent PI changes in relation to lumbar lordosis during skeletal maturation is unclear. The purpose of this study is to understand how PI, lumbar lordosis, and age are related in children and adolescents. PI, supine lumbar lordosis (SLL), and individual wedging angles of the lumbar vertebral bodies were measured on mid-sagittal reformatted images from 144 abdominal computed tomographic scans of individuals aged 2-20 years old, divided into three separate age categories representing pre-growth spurt (ages 2-9), growth spurt (10-15), and post-growth spurt (16-20). Our results showed that, while SLL significantly increased with age during development, PI did not. Despite the fact that PI hardly changed with age, the difference between PI and SLL decreased nonlinearly with age. SLL did not correlate with PI in the youngest age category, but positively correlated with PI in the middle and oldest age categories. The relationship between lumbar lordosis and PI, which is correlated in adults, was significant in our older age categories and not in our youngest age category. Our results indicate that PI in children and adolescents may have some predictive value for adult lumbar lordosis. Anat Rec, 302:2132-2139, 2019. © 2019 American Association for Anatomy.

Brief Communication: Stand and shuffle: when does it make energetic sense?

Many reasons for the emergence of bipedalism have been proposed, including postural arguments which highlight that a sub-optimal form of bipedalism ("shuffling") might have been used by protohominids to cover short distances between resources that require bipedal standing. Bipedal shuffling may have been employed because it avoids the cost of raising the trunk from the quadrupedal orientation, which we assume is the habitual locomotor stance of protohominids. To date, these postural proposals have not been analytically assessed, a lack we rectify herein. Our model seeks to specify a threshold distance, below which bipedal shuffling uses less energy than quadrupedalism. Parameters for the model include the mechanical cost of transport, the ratio of bipedal to quadrupedal cost, and the cost associated with raising the trunk. We found that, using reasonable model parameters, open distances of approximately 9-16 m support the use of bipedal shuffling. Protohominids may have used shuffling as an energetically effective way to traverse between resource patches.

Modern humans are not (quite) isometric.

Allometric relationships are important sources of information for many types of anthropological and biological research. The baseline for all allometric relationships is isometry (or geometric similarity), the principal that shape is invariant of size. Here, we formally test for geometric similarity in modern humans, looking at the maximum lengths of four long bones (humerus, radius, femur, and tibia). We use Jolicoeur's multivariate allometry method to examine globally distributed samples of human populations, both collectively and individually. Results indicate that humans are not geometrically similar, although morphological deviations from isometry are small.

Young's Modulus and Load Complexity: Modeling Their Effects on Proximal Femur Strain.

Finite element analysis (FEA) is a powerful tool for evaluating questions of functional morphology, but the application of FEA to extant or extinct creatures is a non-trivial task. Three categories of input data are needed to appropriately implement FEA: geometry, material properties, and boundary conditions. Geometric data are relatively easily obtained from imaging techniques, but often material properties and boundary conditions must be estimated. Here we conduct sensitivity analyses of the effect of the choice of Young's Modulus for elements representing trabecular bone and muscle loading complexity on the proximal femur using a finite element mesh of a modern human femur. We found that finite element meshes that used a Young's Modulus between 500 and 1,500 MPa best matched experimental strains. Loading scenarios that approximated the insertion sites of hip musculature produced strain patterns in the region of the greater trochanter that were different from scenarios that grouped muscle forces to the superior greater trochanter, with changes in strain values of 40% or more for 20% of elements. The femoral head, neck, and proximal shaft were less affected (e.g. approximately 50% of elements changed by 10% or less) by changes in the location of application of muscle forces. From our sensitivity analysis, we recommend the use of a Young's Modulus for the trabecular elements of 1,000 MPa for the proximal femur (range 500-1,500 MPa) and that the muscular loading complexity be dependent on whether or not strains in the greater trochanter are the focus of the analytical question. Anat Rec, 301:1189-1202, 2018. © 2018 Wiley Periodicals, Inc.

Energy expenditure in people with transtibial amputation walking with crossover and energy storing prosthetic feet: A randomized within-subject study.

BACKGROUND: Energy storing feet are unable to reduce the energy required for normal locomotion among people with transtibial amputation. Crossover feet, which incorporate aspects of energy storing and running specific feet, are designed to maximize energy return while providing stability for everyday activities. RESEARCH QUESTION: Do crossover prosthetic feet reduce the energy expenditure of walking across a range of speeds, when compared with energy storing feet among people with transtibial amputation due to non-dysvascular causes? METHODS: A randomized within-subject study was conducted with a volunteer sample of twenty-seven adults with unilateral transtibial amputation due to non-dysvascular causes. Participants were fit with two prostheses. One had an energy storing foot (Össur Variflex) and the other a crossover foot (Össur Cheetah Xplore). Other components, including sockets, suspension, and interface were standardized. Energy expenditure was measured with a portable respirometer (Cosmed K4b2) while participants walked on a treadmill at self-selected slow, comfortable, and fast speeds with each prosthesis. Gross oxygen consumption rates (VO2 ml/min) were compared between foot conditions. Energy storing feet were used as the baseline condition because they are used by most people with a lower limb prosthesis. Analyses were performed to identify people who may benefit from transition to crossover feet. RESULTS: On average, participants had lower oxygen consumption in the crossover foot condition compared to the energy storing foot condition at each self-selected walking speed, but this difference was not statistically significant. Participants with farther six-minute walk test distances, higher daily step counts, and higher Medicare Functional Classification Levels at baseline were more likely to use less energy in the crossover foot. SIGNIFICANCE: Crossover feet may be most beneficial for people with higher activity levels and physical fitness. Further research is needed to examine the effect of crossover feet on energy expenditure during high-level activities.

Laboratory- and community-based health outcomes in people with transtibial amputation using crossover and energy-storing prosthetic feet: A randomized crossover trial.

Contemporary prosthetic feet are generally optimized for either daily or high-level activities. Prosthesis users, therefore, often require multiple prostheses to participate in activities that span a range of mobility. Crossover feet (XF) are designed to increase the range of activities that can be performed with a single prosthesis. However, little evidence exists to guide clinical prescription of XF relative to traditional energy storing feet (ESF). The objective of this study was to assess the effects of XF and ESF on health outcomes in people with transtibial amputation. A randomized crossover study was conducted to assess changes in laboratory-based (endurance, perceived exertion, walking performance) and community-based (step activity and self-reported mobility, fatigue, balance confidence, activity restrictions, and satisfaction) outcomes. Twenty-seven participants were fit with XF and ESF prostheses with standardized sockets, interfaces, and suspensions. Participants were not blinded to the intervention, and wore each prosthesis for one month while their steps were counted with an activity monitor. After each accommodation period, participants returned for data collection. Endurance and perceived exertion were measured with the Six-Minute Walk Test and Borg-CR100, respectively. Walking performance was measured using an electronic walkway. Self-reported mobility, fatigue, balance confidence, activity restrictions, and satisfaction were measured with survey instruments. Participants also reported foot preferences upon conclusion of the study. Differences between feet were assessed with a crossover analysis. While using XF, users experienced improvements in most community-based outcomes, including mobility (p = .001), fatigue (p = .001), balance confidence (p = .005), activity restrictions (p = .002), and functional satisfaction (p < .001). Participants also exhibited longer sound side steps in XF compared to ESF (p < .001). Most participants (89%) reported an overall preference for XF; others (11%) reported no preference. Results indicate that XF may be a promising alternative to ESF for people with transtibial amputation who engage in a range of mobility activities. TRIAL REGISTRATION: ClinicalTrials.gov NCT02440711.

Joint-Preserving Osteotomies for Malaligned Intraarticular Calcaneal Fractures.

Intraarticular calcaneal fracture treatments that result in malalignment often require reconstructive surgery. Seven cases are used to demonstrate the intricacies of reconstructive case management. Reestablishment of calcaneal height, length, orientation, and position relative to the other tarsals is necessary to reestablish appropriate foot function. Inherent or acquired gastrocnemius equinus should be treated with recession to reduce destructive forces on the reconstruction.

Incidence of Preoperative Deep Vein Thrombosis in Calcaneal Fractures.

OBJECTIVES: This study examined the incidence and risk factors of preoperative deep vein thrombosis (DVT) in patients presenting to an outpatient setting with an isolated calcaneal fracture. DESIGN: Retrospective chart review. SETTING: All patients included in the study presented to the treating surgeon at a Level I trauma center with isolated calcaneal fractures as an outpatient between 2005 and 2013. METHODS: These patients were either referred from outside hospitals, had been evaluated in the emergency department initially and presented for definitive care, or presented initially to the outpatient clinic. Patients included were over the age of 18, had a preoperative duplex ultrasonography of bilateral lower extremities per the treating surgeon's protocol, and had at minimum 6 weeks follow-up. Patients were excluded if they were a polytrauma, had a documented hypercoagulable state, or were on baseline pharmacologic anticoagulation for another condition. All patients had a preoperative duplex ultrasound of both lower extremities to evaluate for DVT at least 7 days after injury. MAIN OUTCOME MEASURE: Patients found to have a preoperative DVT were compared with those who did not have preoperative DVT for possible risk factors. RESULTS: One hundred fifty-nine patients qualified for our study and of these, 19 (12%) were found to have a DVT preoperatively, almost all of which were in distal veins. All risk factors, including age, sex, and body mass index were analyzed as continuous variables. Older age was found to be a risk factor for DVT (P = 0.009, Odds Ratio = 1.06, 95% CI, 1.01-1.11). All other predictor variables, including body mass index (P = 0.05) and sex (P = 0.08), were not statistically significant predictors in our sample. CONCLUSIONS: The incidence of preoperative DVT found here is almost 2 times as high as any previously published examination of lower extremity injuries. Physicians should be aware of this increase so they may counsel patients about the risks of DVTs and the likelihood of any sequelae from developing a DVT that may affect a patient's recovery. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Wound healing complications in closed and open calcaneal fractures.

OBJECTIVES: To determine the rate of serious infection in closed and open calcaneal fractures that were treated with open reduction and internal fixation (ORIF) via an extensile lateral approach. DESIGN: Retrospective review. SETTING: Level 1 trauma center. PATIENTS: Two groups of patients with calcaneal fractures treated with ORIF via an extensile lateral approach by the senior author are included. The first group contained 341 closed fractures in patients injured during the period 1994-2000. The second group included 39 open calcaneal fractures in patients injured during the period 1989-2000. MAIN OUTCOME MEASUREMENTS: The age, sex, pre-existing medical conditions, compliance history, mechanism of injury, soft tissue status, presence of serious infection, and treatment of the infection were recorded for each patient. Data were gathered by review of patient records and by telephone interview when medical records were incomplete. The rate of serious infection in the closed and open samples was determined. A literature review yielded 15 reports that contained sufficient detail to calculate the rate of serious infection. RESULTS: Of patients, 1.8% with closed fractures and 7.7% with open fractures experienced serious infections that required intervention beyond oral antibiotics. All of these feet eventually healed their incisions and fractures. The calculations from data obtained from the literature review indicate rates of serious infection of 0-20% for closed and 19-31% for open calcaneal fractures. CONCLUSIONS: When done correctly in compliant patients, ORIF for calcaneal fractures via the extensile lateral approach (which allows for restoration of calcaneal anatomy after substantial disruption) does not expose the patient to undue risk of serious infection.

Heritability estimation of osteoarthritis in the pig-tailed macaque (Macaca nemestrina) with a look toward future data collection.

We examine heritability estimation of an ordinal trait for osteoarthritis, using a population of pig-tailed macaques from the Washington National Primate Research Center (WaNPRC). This estimation is non-trivial, as the data consist of ordinal measurements on 16 intervertebral spaces throughout each macaque's spinal cord, with many missing values. We examine the resulting heritability estimates from different model choices, and also perform a simulation study to compare the performance of heritability estimation with these different models under specific known parameter values. Under both the real data analysis and the simulation study, we find that heritability estimates from an assumption of normality of the trait differ greatly from those of ordered probit regression, which considers the ordinality of the trait. This finding indicates that some caution should be observed regarding model selection when estimating heritability of an ordinal quantity. Furthermore, we find evidence that our real data have little information for valid heritability estimation under ordered probit regression. We thus conclude with an exploration of sample size requirements for heritability estimation under this model. For an ordinal trait, an incorrect assumption of normality can lead to severely biased heritability estimation. Sample size requirements for heritability estimation of an ordinal trait under the threshold model depends on the pedigree structure, trait distribution and the degree of relatedness between each phenotyped individual. Our sample of 173 monkeys did not have enough information from which to estimate heritability, but estimable heritability can be obtained with as few as 180 related individuals under certain scenarios examined here.

Kirschner wire bending.

Although Kirschner wires are useful implants in many situations, migration of the wire and irritation of the surrounding soft tissues are common complications. Seven steps are described herein, which result in a Kirschner wire that is bent 180° angle, providing a smooth anchor into bone. Use of this technique produces implants that provide stable fixation with few soft tissue complications.

Sex differences in spinal osteoarthritis in humans and rhesus monkeys (Macaca mulatta).

STUDY DESIGN: Retrospective study of male and female spinal osteoarthritis, characterized by lateral spine thoracolumbar radiographs, in humans and nonhuman primates. OBJECTIVE: To characterize differences in prevalence and vertebral distribution of spinal osteoarthritis between men and women, between male and female macaques, and between the 2 phylogenetically related genera. SUMMARY OF BACKGROUND DATA: Naturally occurring spinal osteoarthritis manifests similarly in humans and rhesus macaques. Other types of osteoarthritis particularly of the knee and hip have revealed sex differences in humans. In regard to spinal osteoarthritis, sex differences have been noted but without consistent results. Sex differences in macaques have not been examined. METHODS: Radiographical evidence of disc space narrowing and osteophytosis was assessed using an atlas-scoring method. Prevalence was determined according to sex, age, body mass (for macaques only), and spinal location (human T4-L5; macaque T8-L7). RESULTS: Average scores in macaques differed between the sexes, but they did not differ between men and women. The pattern of involvement along the spine was the same in male and female monkeys but differed between men and women: women had more thoracic involvement and men had more lumbar involvement. Overall, monkeys had a significantly higher prevalence of osteoarthritis than humans. CONCLUSION: The appearance of sex differences in the prevalence of osteoarthritis is most likely a proxy measure for the effect of body mass. Sex differences were apparent in monkeys due to the fact that males are significantly heavier than females. No sex difference in prevalence was apparent in humans, and there is substantial overlap in body mass between men and women. Differences in the location of osteoarthritic involvement along the spine between men and women were obscured when only average scores were examined.

Longitudinal study of radiographic spinal osteoarthritis in a macaque model.

Cross-sectional analyses of naturally occurring spinal osteoarthritis (OA) in primates have shown that age and body mass are significant predictors, but whether or not these relationships hold true in longitudinal evaluations remains unclear. Because spinal OA manifests similarly in humans and monkeys and macaque monkeys age >3 times the rate of humans, macaque models offer opportunities for longitudinal study that are difficult in humans. Our objective was to characterize the longitudinal development over 11 years of spinal OA in 68 Macaca mulatta (41 males, 27 females, aged 11-32 years). Average disc space narrowing (DSN) and osteophytosis (OST) scores were computed for the thoracolumbar spine (T8-L7). Our longitudinal analyses confirmed the cross-sectional results: age and body mass (p < 0.001) significantly predicted 50% and 39% of the variability in OST and DSN, respectively. Rates of change in DSN, but not OST, were associated with age at first radiograph. This study represents the first long-term longitudinal assessment of OA in primates and establishes that the relationship among the covariates in the cross-sectional and longitudinal approaches is similar.