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1.
J Hand Surg Am ; 2023 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-37256249

RESUMO

PURPOSE: This study aimed to compare the success rates of fingertip replantation with and without venous anastomosis. METHODS: This retrospective study included 132 patients with 148 fingertip injuries who had undergone fingertip replantation (Ishikawa's classification I‒IV) between 2003 and 2020 at our hospital. Among them, 117 and 15 were men and women respectively, and their mean age was 43 years. There were 53, 44, and 51 fingertips with Ishikawa subzone II, III, and IV amputations respectively, and no cases were classified as Ishikawa subzone I. Venous anastomosis was performed on 64 fingertips (group A). This was not possible in the remaining 84 fingertips; thus, an external bleeding method was used (group B). Our external bleeding protocol consisted of 4-hourly skin pricks of the distal pulp with a 23-gauge needle for the first 5 days. The analyses included survival rates, hemoglobin levels (Hb), and blood transfusions administered. RESULTS: The overall survival rate was 90.5% (134 of 148). In group A, survival was achieved in 92.3%, 100%, and 94.3% of those with subzones II, III, and IV amputations, respectively. In group B, survival was achieved in 100%, 82.1%, and 62.5% of those with subzones II, III, and IV, respectively. Subzone IV in group B showed a significantly lower rate of replantation success. In groups A and B, the preoperative and 7-day postoperative Hb levels were 14.5 g/dL and 14.6 g/dL, and 11.3 g/dL, and 11.6 g/dL, respectively. In addition, blood transfusion was required for five patients (7.9%) in group A and six patients (7.9%) in group B. Thus, the Hb levels and blood transfusion administered were similar between the two groups. CONCLUSIONS: Subzone IV is an important threshold for artery-only replantation. Furthermore, our external bleeding protocol is a safe and effective method. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

2.
J Orthop Sci ; 28(2): 364-369, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34922806

RESUMO

BACKGROUND: Ulnar shortening osteotomy (USO), as its name implies, is used to shorten the ulna. It subsequently tightens the triangular fibrocartilage complex (TFCC) and ulnar wrist. TFCC foveal insertion is a primary stabilizer of the distal radioulnar joint. It is unclear whether USO is effective in TFCC foveal injuries. The purpose of this study was to review the clinical outcomes of ulnar shortening osteotomies with and without TFCC foveal injuries. METHODS: We retrospectively reviewed patients with ulnar wrist pain treated with USO and wrist arthroscopy including the distal radioulnar joint (DRUJ). Sixty-five patients were included in this study. An algorithm was used to guide surgical decision-making. After arthroscopic confirmation of ulnar impaction syndrome, we performed USO with a locking compression plate (mean length of shortening, 2.7 mm; range, 1-7.5 mm). The flattened TFCC disc due to ulnar shortening was confirmed arthroscopically. If the DRUJ was unstable after USO, we repaired the TFCC foveal insertion. RESULTS: There were 32 post-traumatic and 33 idiopathic cases. We detected TFCC disc injuries in 34 wrists and TFCC foveal injuries in 33 wrists; both types were found in 15 wrists. TFCC foveal injuries were not significantly correlated with patient age, history of trauma, or clinical outcome. Most patients showed good clinical outcomes; 31 of 65 patients had preoperative DRUJ instability, with a significant number having foveal but not disc injuries. CONCLUSION: USO achieved reasonable outcomes, even in patients with TFCC foveal injuries. In cases demonstrating ulnar impaction, USO should be prioritized over TFCC repair.


Assuntos
Instabilidade Articular , Fibrocartilagem Triangular , Traumatismos do Punho , Humanos , Fibrocartilagem Triangular/diagnóstico por imagem , Fibrocartilagem Triangular/cirurgia , Fibrocartilagem Triangular/lesões , Estudos Retrospectivos , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/cirurgia , Osteotomia , Traumatismos do Punho/diagnóstico por imagem , Traumatismos do Punho/cirurgia , Artroscopia , Instabilidade Articular/diagnóstico por imagem , Instabilidade Articular/etiologia , Instabilidade Articular/cirurgia , Ulna/diagnóstico por imagem , Ulna/cirurgia
3.
J Orthop Sci ; 2023 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-37149481

RESUMO

BACKGROUND: Biodegradable synthetic nerve conduits have become widely used for peripheral nerve injuries. Recently, bioabsorbable collagen conduits filled with collagen fibers (Renerve®) are commercially available in Japan. We investigated the clinical efficacy and safety of Renerve® conduits for digital nerve repair. PATIENTS AND METHODS: We retrospectively reviewed data of patients who underwent digital nerve repair using Renerve® conduits between August 2017 and February 2022 at our hospital and were followed up for at least 12 months. Seventeen patients (20 nerves) with a median age of 46.5 years (interquartile rage: 26-48 years) were included in the analysis. We analyzed sensory nerve function recovery and residual pain or uncomfortable tingling, as well as safety outcomes. The relationship between nerve defect length and sensory function data was assessed using Spearman's rank correlation. RESULTS: Sensory nerve function at 12 months postoperatively was excellent in six, good in 10, and poor in four nerves, and that at the final follow-up (median period, 24 months; range, 12-30 months) was excellent in nine, good in 10, and poor in one nerve. All nerves with a defect length of <12 mm had excellent or good sensory outcomes. At 12 months postoperatively, the correlation coefficients between nerve defect length and Semmes-Weinstein monofilament test results, static two-point discrimination, and dynamic two-point discrimination were 0.35 (p = 0.131), 0.397 (p = 0.0827), and 0.451 (p = 0.0461), respectively. Residual pain or tingling sensation were observed in four nerves at the final follow-up. No postoperative complications were observed in any of the patients. CONCLUSIONS: This study demonstrated the clinical efficacy and safety of Renerve® conduits for digital nerve repair. Our results will be useful in clinical practice because of the scarcity of real-world data on the use of Renerve® conduits for digital nerve repair.

4.
Sensors (Basel) ; 22(19)2022 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-36236295

RESUMO

A wirelessly powered four-channel neurostimulator was developed for applying selective Functional Electrical Stimulation (FES) to four peripheral nerves to control the ankle and knee joints of a rat. The power of the neurostimulator was wirelessly supplied from a transmitter device, and the four nerves were connected to the receiver device, which controlled the ankle and knee joints in the rat. The receiver device had functions to detect the frequency of the transmitter signal from the transmitter coil. The stimulation site of the nerves was selected according to the frequency of the transmitter signal. The rat toe position was controlled by changing the angles of the ankle and knee joints. The joint angles were controlled by the stimulation current applied to each nerve independently. The stimulation currents were adjusted by the Proportional Integral Differential (PID) and feed-forward control method through a visual feedback control system, and the walking trajectory of a rat's hind leg was reconstructed. This study contributes to controlling the multiple joints of a leg and reconstructing functional motions such as walking using the robotic control technology.


Assuntos
Terapia por Estimulação Elétrica , Animais , Tornozelo , Articulação do Tornozelo , Terapia por Estimulação Elétrica/métodos , Articulação do Joelho/fisiologia , Ratos , Caminhada/fisiologia
5.
J Orthop Sci ; 27(6): 1338-1341, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34598846

RESUMO

BACKGROUND: Most surgeons are unaware that idiopathic neuropathy, which occurs independently of mechanical injury, can present as postoperative peripheral neuropathy. The aim of this study was to reveal the presence of postoperative neuropathy considered to be induced by surgical stress and to make surgeons aware that idiopathic neuropathy can occur postoperatively. METHODS: We conducted a survey among orthopedic surgeons regarding patients with postoperative neuropathies of unknown cause. For each case, the type of neuropathy, preceding surgery and anesthesia, patient background, clinical findings, and clinical course were investigated. RESULTS: Seven patients were identified. The mean time from surgery to the onset of neuropathy was 9.3 days (range 1-15 days). Five of the patients fully recovered spontaneously within 1 year, while the remaining two underwent neurolysis. One patient presented with hourglass-like constrictions in the radial nerve. No inflammatory cells were found in the epineurium of the affected nerve. CONCLUSIONS: Although it is rare, postoperative idiopathic neuropathy occurs in clinical practice, and it is crucial that surgeons recognize the existence of this neuropathy to elucidate its pathogenesis as well as to reduce the risk of litigation.


Assuntos
Doenças do Sistema Nervoso Periférico , Humanos , Doenças do Sistema Nervoso Periférico/diagnóstico , Doenças do Sistema Nervoso Periférico/etiologia , Nervos Periféricos/patologia , Nervos Periféricos/cirurgia , Procedimentos Neurocirúrgicos , Constrição Patológica/cirurgia , Período Pós-Operatório
6.
Int J Mol Sci ; 23(15)2022 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-35955906

RESUMO

Neural cell transplantation targeting peripheral nerves is a potential treatment regime for denervated muscle atrophy. This study aimed to develop a new therapeutic technique for intractable muscle atrophy by the xenotransplantation of neural stem cells derived from pig fetuses into peripheral nerves. In this study, we created a denervation model using neurotomy in nude rats and transplanted pig-fetus-derived neural stem cells into the cut nerve stump. Three months after transplantation, the survival of neural cells, the number and area of regenerated axons, and the degree of functional recovery by electrical stimulation of peripheral nerves were compared among the gestational ages (E 22, E 27, E 45) of the pigs. Transplanted neural cells were engrafted at all ages. Functional recovery by electric stimulation was observed at age E 22 and E 27. This study shows that the xenotransplantation of fetal porcine neural stem cells can restore denervated muscle function. When combined with medical engineering, this technology can help in developing a new therapy for paralysis.


Assuntos
Denervação Muscular , Regeneração Nervosa , Animais , Músculo Esquelético , Músculos , Atrofia Muscular , Regeneração Nervosa/fisiologia , Ratos , Suínos , Transplante Heterólogo
7.
Int J Mol Sci ; 23(15)2022 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-35955890

RESUMO

Promising treatments for upper motor neuron disease are emerging in which motor function is restored by brain-computer interfaces and functional electrical stimulation. At present, such technologies and procedures are not applicable to lower motor neuron disease. We propose a novel therapeutic strategy for lower motor neuron disease and injury integrating neural stem cell transplantation with our new functional electrical stimulation control system. In a rat sciatic nerve transection model, we transplanted embryonic spinal neural stem cells into the distal stump of the peripheral nerve to reinnervate denervated muscle, and subsequently demonstrated that highly responsive limb movement similar to that of a healthy limb could be attained with a wirelessly powered two-channel neurostimulator that we developed. This unique technology, which can reinnervate and precisely move previously denervated muscles that were unresponsive to electrical stimulation, contributes to improving the condition of patients suffering from intractable diseases of paralysis and traumatic injury.


Assuntos
Doença dos Neurônios Motores , Células-Tronco Neurais , Animais , Estimulação Elétrica , Doença dos Neurônios Motores/terapia , Neurônios Motores/fisiologia , Músculo Esquelético/inervação , Regeneração Nervosa/fisiologia , Ratos , Ratos Endogâmicos F344 , Nervo Isquiático/fisiologia , Transplante de Células-Tronco
8.
Muscle Nerve ; 61(3): 408-415, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31883124

RESUMO

INTRODUCTION: In this study we aimed to clarify the association between interleukin-6 (IL-6) secretion in fibroblasts in carpal tunnel syndrome (CTS) patients and their biophysical parameters, including association with trigger finger and whether tranilast inhibits IL-6 secretion in fibroblasts. METHODS: Fibroblasts were obtained from tenosynovial tissue harvested from idiopathic CTS patients undergoing carpal tunnel release and tenosynovectomy and cultured in media containing tranilast with or without tumor necrosis-α (TNF-α) or interleukin-1ß (IL-1ß). Their proliferation was evaluated and secreted IL-6 levels and IL-6 mRNA expression were quantified. Correlations between IL-6 concentration and patient characteristics were examined. RESULTS: IL-6 secretion was significantly associated with trigger finger (P = .001). Tranilast inhibited fibroblast proliferation in a dose-dependent manner and suppressed IL-6 secretion. DISCUSSION: IL-6 overproduction in tenosynovial tissue may account for the association between CTS and trigger finger. Future studies should investigate whether tranilast can be used to treat patients with CTS.


Assuntos
Antialérgicos/farmacologia , Síndrome do Túnel Carpal/metabolismo , Fibroblastos/efeitos dos fármacos , Fibroblastos/metabolismo , Interleucina-6/metabolismo , Dedo em Gatilho/metabolismo , ortoaminobenzoatos/farmacologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/metabolismo , Síndrome do Túnel Carpal/complicações , Proliferação de Células , Células Cultivadas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Dedo em Gatilho/complicações , Dedo em Gatilho/diagnóstico
9.
BMC Musculoskelet Disord ; 21(1): 173, 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32178665

RESUMO

BACKGROUND: Hand osteoarthritis (OA) has a wide spectrum of clinical presentations and physical function is one of the core domains where patients suffer. The Functional Index for Hand Osteoarthritis (FIHOA) is a leading assessment tool for hand OA-related functional impairment. Our objective was to make a Japanese version of FIHOA (J-FIHOA) and validate it among Japanese hand OA patients. METHODS: Forward and backward translation processes were completed to create a culturally adapted J-FIHOA. A prospective, observational multicenter study was undertaken for the validation process. Seventeen collaborating hospitals recruited Japanese hand OA patients who met the American College of Rheumatology criteria. A medical record review and responses to the following patient-rated questionnaires were collected: J-FIHOA, Hand20, Health Assessment Questionnaire (HAQ), numerical rating scale for pain (NRS pain) and Short Form 36 Health Survey (SF-36). We explored the structure of J-FIHOA using factor analysis. Cronbach's alpha coefficients and item-total correlations were calculated. Correlations between J-FIHOA and other questionnaires were evaluated for construct validity. Participants in clinically stable conditions repeated J-FIHOA at a one- to two-week interval to assess test-retest reliability. To evaluate responsiveness, symptomatic patients who started new pharmacological treatments had a 1-month follow-up visit and completed the questionnaires twice. Effect size (ES) and standardized response mean (SRM) were calculated with pre- and post-treatment data sets. We assessed responsiveness, comparing ES and SRM of J-FIHOA with other questionnaires (construct approach). RESULTS: A total of 210 patients participated. J-FIHOA had unidimensional structure. Cronbach's alphas (0.914 among females and 0.929 among males) and item-total correlations (range, 0.508 to 0.881) revealed high internal consistency. Hand20, which measures upper extremity disability, was strongly correlated with J-FIHOA (r = 0.82) while the mental and role-social components of SF-36 showed no correlations (r = - 0.24 and - 0.26, respectively). Intraclass correlation coefficient for test-retest reliability was 0.83 and satisfactory. J-FIHOA showed the highest ES and SRM (- 0.68 and - 0.62, respectively) among all questionnaires, except for NRS pain. CONCLUSIONS: Our results showed J-FIHOA had good measurement properties to assess physical function in Japanese hand OA patients both for ambulatory follow-up in clinical practice, and clinical research and therapeutic trials.


Assuntos
Comparação Transcultural , Articulação da Mão/patologia , Osteoartrite/diagnóstico , Osteoartrite/etnologia , Inquéritos e Questionários/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Japão/etnologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Reprodutibilidade dos Testes
10.
Sensors (Basel) ; 20(8)2020 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-32295158

RESUMO

Peripheral nerve disconnections cause severe muscle atrophy and consequently, paralysis of limbs. Reinnervation of denervated muscle by transplanting motor neurons and applying Functional Electrical Stimulation (FES) onto peripheral nerves is an important procedure for preventing irreversible degeneration of muscle tissues. After the reinnervation of denervated muscles, multiple peripheral nerves should be stimulated independently to control joint motion and reconstruct functional movements of limbs by the FES. In this study, a wirelessly powered two-channel neurostimulator was developed with the purpose of applying selective FES to two peripheral nerves-the peroneal nerve and the tibial nerve in a rat. The neurostimulator was designed in such a way that power could be supplied wirelessly, from a transmitter coil to a receiver coil. The receiver coil was connected, in turn, to the peroneal and tibial nerves in the rat. The receiver circuit had a low pass filter to allow detection of the frequency of the transmitter signal. The stimulation of the nerves was switched according to the frequency of the transmitter signal. Dorsal/plantar flexion of the rat ankle joint was selectively induced by the developed neurostimulator. The rat ankle joint angle was controlled by changing the stimulation electrode and the stimulation current, based on the Proportional Integral (PI) control method using a visual feedback control system. This study was aimed at controlling the leg motion by stimulating the peripheral nerves using the neurostimulator.


Assuntos
Articulação do Tornozelo/fisiologia , Estimulação Elétrica/métodos , Animais , Estimulação Elétrica/instrumentação , Eletrodos , Retroalimentação Sensorial , Nervo Fibular/fisiologia , Ratos , Nervo Tibial/fisiologia , Tecnologia sem Fio
11.
Acta Orthop Belg ; 84(1): 78-83, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30457504

RESUMO

The purpose of this study was to compare the treatment results of sonography-guided arthroscopic excision for volar and dorsal wrist ganglions. A total of 42 patients with wrist ganglions underwent sonography-guided arthroscopic resection. Clinical outcome measures included wrist range of motion, grip strength, patient-rated questionnaire Hand20, and numerical pain rating scale. All patients were assessed for recurrence throughout the follow-up period. Ganglions were located at the dorsal wrist in 26 cases and at the volar wrist in 16 cases. The mean Hand20 and pain scores were significantly improved after sonography-guided arthroscopic resection for both volar and dorsal wrist ganglions. Recurrence was seen in six cases (23%) of dorsal wrist ganglion but no cases of volar wrist ganglion (P < .05). The use of sonography-guided arthroscopic ganglion excision is better for treating volar wrist ganglion than dorsal wrist ganglion.


Assuntos
Artroscopia/métodos , Cistos Glanglionares/cirurgia , Articulação do Punho/cirurgia , Punho/cirurgia , Adolescente , Adulto , Idoso , Feminino , Cistos Glanglionares/diagnóstico por imagem , Cistos Glanglionares/fisiopatologia , Força da Mão/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular/fisiologia , Resultado do Tratamento , Ultrassonografia , Punho/diagnóstico por imagem , Punho/fisiopatologia , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/fisiopatologia , Adulto Jovem
12.
J Orthop Sci ; 22(2): 289-294, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27916338

RESUMO

BACKGROUND: A forearm band is frequently used for lateral epicondylitis worldwide. However, evidence regarding its efficacy has been insufficient. The objective of this prospective, randomized, controlled trial was to analyze the effects of a forearm band for treatment of lateral epicondylitis at 1, 3, 6, and 12 months. METHODS: Patients with lateral epicondylitis were randomly allocated into a band (n = 55) or non-band (n = 55) group. Patients in the band group were instructed to wear a forearm band for more than 6 h daily for at least 6 months. Patients in both groups were instructed to perform wrist extensor stretching exercises for 30 s, 3 times daily, for 6 months. Hand10, pain, and satisfaction scores, and proportions of positive physical examinations, including tenderness assessment, Thomsen test, and middle finger extension test, were evaluated at 1, 3, 6, and 12 months after enrollment. RESULTS: There were no significant differences between the band and non-band groups with regard to Hand10, pain, or satisfaction scores at 1, 3, 6, and 12 months. Likewise, there was no significant difference in proportions of positive physical examinations between groups at 1, 3, 6, and 12 months. CONCLUSION: The results of the current study suggest that a forearm band may have no more than a placebo effect, and do not support the use of a forearm band based on its effectiveness.


Assuntos
Terapia por Exercício/métodos , Aparelhos Ortopédicos , Medição da Dor , Amplitude de Movimento Articular/fisiologia , Cotovelo de Tenista/reabilitação , Adulto , Terapia Combinada , Seguimentos , Força da Mão , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos , Índice de Gravidade de Doença , Cotovelo de Tenista/diagnóstico , Fatores de Tempo , Resultado do Tratamento
13.
BMC Musculoskelet Disord ; 17: 144, 2016 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-27039373

RESUMO

BACKGROUND: Recent advances in imaging modalities have enabled three-dimensional preoperative simulation. A four-dimensional preoperative simulation system would be useful for debridement arthroplasty of primary degenerative elbow osteoarthritis because it would be able to detect the impingement lesions. METHODS: We developed a four-dimensional simulation system by adding the anatomical axis to the three-dimensional computed tomography scan data of the affected arm in one position. Eleven patients with primary degenerative elbow osteoarthritis were included. A "two rings" method was used to calculate the flexion-extension axis of the elbow by converting the surface of the trochlea and capitellum into two rings. A four-dimensional simulation movie was created and showed the optimal range of motion and the impingement area requiring excision. To evaluate the reliability of the flexion-extension axis, interobserver and intraobserver reliabilities regarding the assessment of bony overlap volumes were calculated twice for each patient by two authors. Patients were treated by open or arthroscopic debridement arthroplasties. Pre- and postoperative examinations included elbow range of motion measurement, and completion of the patient-rated questionnaire Hand20, Japanese Orthopaedic Association-Japan Elbow Society Elbow Function Score, and the Mayo Elbow Performance Score. RESULTS: Measurement of the bony overlap volume showed an intraobserver intraclass correlation coefficient of 0.93 and 0.90, and an interobserver intraclass correlation coefficient of 0.94. The mean elbow flexion-extension arc significantly improved from 101° to 125°. The mean Hand20 score significantly improved from 52 to 22. The mean Japanese Orthopaedic Association-Japan Elbow Society Elbow Function Score significantly improved from 67 to 88. The mean Mayo Elbow Performance Score significantly improved from 71 to 91 at the final follow-up evaluation. CONCLUSION: We showed that four-dimensional, preoperative simulation can be generated by adding the rotation axis to the one-position, three-dimensional computed tomography image of the affected arm. This method is feasible for elbow debridement arthroplasty.


Assuntos
Artroplastia/métodos , Simulação por Computador , Desbridamento/métodos , Articulação do Cotovelo/diagnóstico por imagem , Articulação do Cotovelo/cirurgia , Tomografia Computadorizada Quadridimensional/métodos , Interpretação de Imagem Assistida por Computador/métodos , Osteoartrite/diagnóstico por imagem , Osteoartrite/cirurgia , Cirurgia Assistida por Computador/métodos , Idoso , Artroplastia/efeitos adversos , Fenômenos Biomecânicos , Desbridamento/efeitos adversos , Articulação do Cotovelo/fisiopatologia , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Osteoartrite/fisiopatologia , Complicações Pós-Operatórias/etiologia , Valor Preditivo dos Testes , Amplitude de Movimento Articular , Reprodutibilidade dos Testes , Cirurgia Assistida por Computador/efeitos adversos , Resultado do Tratamento
14.
Nagoya J Med Sci ; 77(1-2): 253-63, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25797991

RESUMO

Transplantation of motoneurons (MN) into the peripheral nerve to provide a source of neurons for muscle reinnervation, termed motoneuron integrated striated muscle (MISM), may provide the potential to restore functional muscle activity, when combined with computer-programmed functional electrical stimulation (FES). The number of MNs required to restore innervation to denervated muscles in adult Fischer 344 rats was investigated by comparing two groups, one transplanted with 2 × 10(5) cells (group A) and the other with 1 × 10(6) cells (group B). Twelve weeks after transplantation, electrophysiological analysis, muscle function analysis, and tissue analysis were performed. The mean motor nerve conduction velocity was faster (12.4 ± 1.0 m/s vs. 8.5 ± 0.7 m/s, P = 0.011) and the mean amplitude of compound muscle action potential was larger (1.6 ± 0.4 mV vs. 0.7 ± 0.2 mV, P = 0.034) in group B. The dorsiflexed ankle angle was larger in group B (27 ± 5° vs. 75 ± 8°, P = 0.02). The mean myelinated axon number in the peroneal nerve and the proportion of reinnervated motor end plates were also greater in group B (317 ± 33 vs. 104 ± 17, 87.5 ± 3.4% vs. 40.6 ± 7.7%; P < 0.01, respectively). When sufficient MNs are transplanted into the peripheral nerve, MISM forms functional motor units. MISM, in conjunction with FES, provides a new treatment strategy for paralyzed muscles.

15.
Int Arch Occup Environ Health ; 87(5): 547-55, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23893254

RESUMO

PURPOSE: The Hand20 is an outcome assessment tool developed in Japan to measure upper extremity disability. The purpose of this study was to investigate occupational musculoskeletal disorders in the upper extremity of hospital personnel and to obtain normative data for the Hand20 in a nonclinical population. METHODS: A cross-sectional questionnaire study was carried out among 2,600 researchers and staff members of the Faculty of Medicine and its affiliated hospital. RESULTS: There were 1,120 responders who went to their daily work without consulting a doctor about any upper extremity disorders, and 232 of these responders complained of upper extremity pain. The mean Hand20 score was 2.67 [standard deviation (SD) 7.06]. Women tended to have significantly higher total Hand20 scores than men (mean ± SD: men = 2.03 ± 5.15, women = 2.94 ± 7.71, p < 0.01). The Hand20 score tended to increase in participants over 40 years of age (p < 0.001). Significant differences were not found by work intensity (p = 0.712). Binominal logistic analysis revealed that the risk of a high Hand20 score (over the 75 % inter-quartile range, over 13.1) was greater with increasing age [odd ratios (ORs) 1.051, 1.071, respectively] and female sex (ORs 1.786, 1.966, respectively), and that the risk of upper extremity pain was greater with increasing age (OR 1.051), heavy physical work (OR 2.042), and physical work (OR 1.916). CONCLUSIONS: Females in all age groups and both sexes in middle age or older need to be informed about their higher risk of upper extremity disorders and should be educated about how to avoid work-related musculoskeletal disorders and their progression.


Assuntos
Hospitais Universitários/estatística & dados numéricos , Doenças Musculoesqueléticas/epidemiologia , Doenças Profissionais/epidemiologia , Recursos Humanos em Hospital/estatística & dados numéricos , Extremidade Superior , Adulto , Fatores Etários , Idoso , Estudos Transversais , Avaliação da Deficiência , Feminino , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Ocupações , Fatores Sexuais , Inquéritos e Questionários
16.
J Biomed Mater Res B Appl Biomater ; 112(1): e35369, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-38247253

RESUMO

Peripheral nerve injuries (PNIs) include complete and partial transection, crushing, and chronic compression injuries. Hollow absorbable conduits are used to treat complete transection with short defects, while wrapping the injured part with an absorbent material promotes nerve recovery by inhibiting inflammatory cell infiltration and scar tissue formation in crush injuries. For treatment of partially transected nerve injuries (PTNIs), such as injection-related iatrogenic PNI, whether wrapping the entire nerve, including the injury site, or bridging the transected fascicle with an artificial nerve conduit (ANC) is beneficial remains to be verified. The purpose of this study was to investigate whether wrapping the injured nerve and placing collagen fibers as scaffolds at the nerve defect site contribute to neural recovery in PTNI. A unilateral 5-mm partial nerve defect was created at the mid-thigh level in a rat sciatic nerve injury model. Fifty-four Sprague-Dawley (SD) rats (150-250 g) were divided into three groups (n = 9 each): group 1, collagen fibers were placed in the nerve defect and the sciatic nerve was wrapped with collagen conduit; group 2, the sciatic nerve was wrapped by collagen conduit without collagen fibers; and group 3, nerve defect was reconstructed with collagen-filled conduit. Nerve regeneration was evaluated by analyses of gait, electrophysiology, wet muscle weight, and axon numbers with immunohistochemistry at 12 and 24 weeks. Dorsiflexion angles among all groups improved significantly from 12 to 24 weeks postoperatively. At 24 weeks postoperatively, compound muscle action potential amplitudes (CMAPs) of tibialis anterior were 5.26 ± 4.64, 1.31 ± 1.17, and 0.14 ± 0.24 mV (p < .05), CMAPs of gastrocnemius were 21.3 ± 5.98, 15.4 ± 5.46, and 13.11 ± 3.91 mV in groups 1, 2, and 3, respectively; and the value of group 1 was significantly higher than that of group 3 (p < .05). Axon numbers were 2194 ± 629; 1106 ± 645; and 805 ± 907 in groups 1, 2, and 3, respectively (p < .05). For PTNI reconstruction, artificial nerve wrap (ANW) was superior to ANC. Providing collagen scaffold at the nerve defect site enhanced nerve recovery during reconstruction with ANW.


Assuntos
Traumatismos dos Nervos Periféricos , Ratos , Animais , Traumatismos dos Nervos Periféricos/terapia , Ratos Sprague-Dawley , Nervo Isquiático/cirurgia , Regeneração Nervosa , Colágeno
17.
Qual Life Res ; 22(5): 1145-9, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22820834

RESUMO

PURPOSE: The Hand10 is a self-administered questionnaire for upper extremity disorders. This questionnaire consists of 10 short, easy-to-understand questions and explanatory illustrations. In the shortening and validation process, the Hand10 demonstrated high acceptability and reliability among elderly individuals, with the advantage of being compact. We hypothesized that attached illustrations may contribute to the ability to maintain the psychometric properties of a questionnaire and raise acceptability for the elderly. METHODS: A series of 106 elderly patients with upper extremity disorders, whose symptoms had been stable, completed the Hand10, the Japanese Society for Surgery of the Hand Version of Disability of the Arm, Shoulder and Hand, and the Revised Hasegawa's Dementia Scale. Participants were randomly allocated to receive either the illustrated Hand10 or the unillustrated Hand10. The potential advantages attributed to attached illustrations were investigated. RESULTS: No significant differences were found in baseline demographic data between subjects who received the illustrated and unillustrated questionnaires. The average percentage of items that the elderly patients left unanswered was 0.5 % for the illustrated Hand10 and 3.8 % for the unillustrated Hand10. Instrument test-retest reliability assessed with the intraclass correlation coefficient was 0.92 and 0.86, respectively. CONCLUSION: The use of explanatory illustrations attached to the Hand10 contributed to raise acceptability for elderly patients and were suggested to improve the reproducibility.


Assuntos
Avaliação da Deficiência , Pessoas com Deficiência , Avaliação de Resultados da Assistência ao Paciente , Inquéritos e Questionários , Extremidade Superior/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Indicadores Básicos de Saúde , Humanos , Japão , Masculino , Doenças Musculoesqueléticas/terapia , Psicometria , Qualidade de Vida , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
18.
Nagoya J Med Sci ; 75(1-2): 125-9, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23544276

RESUMO

Surface-based bone hemangiomas are uncommon, mostly occurring in long bones of the lower extremities. Radiographic surface-based bone hemangioma images may present various features that provide a diagnostic challenge. We report a case of surface-based hemangioma of the radius that posed radiological diagnostic difficulties. The tumor size was small and the cortical reaction was subtle. MRI findings were nonspecific and angiography was useful in the assessment of painful but less obvious surface-based bone hemangioma. The patient's pain improved following surgery and no tumor recurrence was observed at 3 years after surgery.


Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Hemangioma/diagnóstico por imagem , Imageamento por Ressonância Magnética , Recidiva Local de Neoplasia/diagnóstico por imagem , Rádio (Anatomia)/diagnóstico por imagem , Neoplasias Ósseas/cirurgia , Feminino , Hemangioma/cirurgia , Humanos , Angiografia por Ressonância Magnética , Recidiva Local de Neoplasia/cirurgia , Osteotomia , Valor Preditivo dos Testes , Radiografia , Rádio (Anatomia)/cirurgia , Resultado do Tratamento , Adulto Jovem
19.
Nagoya J Med Sci ; 75(1-2): 131-7, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23544277

RESUMO

Radial head dislocation associated with plastic bowing of the ulna is classified as a Monteggia equivalent lesion. This injury in children can be treated by closed reduction, but manipulative reduction may not completely correct plastic bowing of the ulna. We encountered two cases of incomplete reduction in which the radial head was reduced in a supination position, but redislocated during rotation from neutral to a pronation position. The patients were treated conservatively using an adjustable hinged elbow splint. Plain radiography at 6 weeks after incomplete closed reduction showed that the radial head was reduced in all positions from supination to pronation; thus, both patients had good outcomes. Our method is non-invasive and may be an option for treatment of incomplete reduction of radial head dislocation with acute plastic bowing of the ulna.


Assuntos
Moldes Cirúrgicos , Articulação do Cotovelo/fisiopatologia , Fixação de Fratura/instrumentação , Luxações Articulares/terapia , Instabilidade Articular/terapia , Fratura de Monteggia/terapia , Rádio (Anatomia)/fisiopatologia , Contenções , Fenômenos Biomecânicos , Criança , Articulação do Cotovelo/diagnóstico por imagem , Desenho de Equipamento , Feminino , Fixação de Fratura/métodos , Humanos , Luxações Articulares/diagnóstico por imagem , Luxações Articulares/fisiopatologia , Instabilidade Articular/diagnóstico por imagem , Instabilidade Articular/fisiopatologia , Masculino , Fratura de Monteggia/diagnóstico por imagem , Fratura de Monteggia/fisiopatologia , Pronação , Radiografia , Rádio (Anatomia)/diagnóstico por imagem , Supinação , Fatores de Tempo , Resultado do Tratamento
20.
Nagoya J Med Sci ; 75(3-4): 181-92, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24640174

RESUMO

A small, light, ball-joint device called PinFix, which can instantly convert a simple percutaneous cross pin fracture fixation system into a rigid external fracture fixation system based on truss structure, was developed. The purpose of this study was to compare the mechanical load and breaking strength of this truss-structure-based fixation system to that of the conventionally used external cantilever structure-based fixation system. Three types of mechanical loading tests, axial, bending, and torsion, were performed on an artificial fractured bone treated with either three-dimensional PinFix fixation, two-dimensional PinFix fixation, or conventional external fixation. The three- and two-dimensional PinFix fixations showed significantly more stiffness than conventional fixation on all three loading tests. Finite element analysis was next performed to calculate the stress distribution of the parts in PinFix and in the conventional fixator. The applied stress to the rod and connectors of PinFix was much less than that of the conventional external fixator. These results reflected the physical characteristic of truss structure in which applied load is converted to pure tension or compression forces along the members of the PinFix. In conclusion, PinFix is a simple fracture fixation system that has a truss-structure with a high rigidity.


Assuntos
Fixadores Externos , Fixação de Fratura/instrumentação , Fraturas Ósseas/cirurgia , Fenômenos Biomecânicos , Força Compressiva , Desenho de Equipamento , Análise de Elementos Finitos , Fixação de Fratura/métodos , Humanos , Teste de Materiais , Estresse Mecânico
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