Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Assunto da revista
País de afiliação
Intervalo de ano de publicação
1.
Amino Acids ; 53(3): 381-393, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33598768

RESUMO

While it has been hypothesized that brown adipocytes responsible for mammalian thermogenesis are absent in birds, the existence of beige fat has yet to be studied directly. The present study tests the hypothesis that beige fat emerges in birds as a mechanism of physiological adaptation to cold environments. Subcutaneous neck adipose tissue from cold-acclimated or triiodothyronine (T3)-treated chickens exhibited increases in the expression of avian uncoupling protein (avUCP, an ortholog of mammalian UCP2 and UCP3) gene and some known mammalian beige adipocyte-specific markers. Morphological characteristics of white adipose tissues of treated chickens showed increased numbers of both small and larger clusters of multilocular fat cells within the tissues. Increases in protein levels of avUCP and mitochondrial marker protein, voltage-dependent anion channel, and immunohistochemical analysis for subcutaneous neck fat revealed the presence of potentially thermogenic mitochondria-rich cells. This is the first evidence that the capacity for thermogenesis may be acquired by differentiating adipose tissue into beige-like fat for maintaining temperature homeostasis in the subcutaneous fat 'neck warmer' in chickens exposed to a cold environment.


Assuntos
Aclimatação/fisiologia , Galinhas/fisiologia , Gordura Subcutânea/metabolismo , Gordura Abdominal/citologia , Gordura Abdominal/metabolismo , Adipócitos Bege/metabolismo , Tecido Adiposo/metabolismo , Animais , Peso Corporal , Temperatura Baixa , Ingestão de Alimentos , Mitocôndrias/metabolismo , Pescoço/fisiologia , Gordura Subcutânea/citologia , Gordura Subcutânea/efeitos dos fármacos , Termogênese/efeitos dos fármacos , Tri-Iodotironina/farmacologia , Proteína Desacopladora 1/genética , Proteína Desacopladora 1/metabolismo , Canais de Ânion Dependentes de Voltagem/metabolismo
SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa