Detalhe da pesquisa
1.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433953
2.
In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.
J Biol Chem
; 289(26): 17980-95, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24782313
3.
Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.
Elife
; 122023 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37737220
4.
Development of an ectopic huLiver model for Plasmodium liver stage infection.
PLoS One
; 18(3): e0279144, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36928885
5.
Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases.
ACS Infect Dis
; 6(5): 1058-1075, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32272012
6.
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
J Med Chem
; 63(9): 4929-4956, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248693
7.
Setting Our Sights on Infectious Diseases.
ACS Infect Dis
; 6(1): 3-13, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31808676
8.
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Sci Transl Med
; 11(521)2019 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31801884
9.
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.
Science
; 365(6456)2019 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467193
10.
Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.
ACS Infect Dis
; 4(4): 508-515, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29336544
11.
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.
ACS Omega
; 3(8): 9227-9240, 2018 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30197997
12.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
13.
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Nat Commun
; 8: 14574, 2017 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262680
14.
The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold.
J Med Chem
; 60(16): 6880-6896, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28806082
15.
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.
J Med Chem
; 60(24): 10118-10134, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148755
16.
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.
Sci Transl Med
; 9(387)2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446690
17.
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.
ACS Infect Dis
; 3(1): 18-33, 2017 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27704782
18.
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
PLoS One
; 11(3): e0149996, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26934697
19.
A broad analysis of resistance development in the malaria parasite.
Nat Commun
; 7: 11901, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27301419
20.
Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold.
J Med Chem
; 60(23): 9911, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29164877