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1.
Appl Opt ; 53(4): A110-3, 2014 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-24514201

RESUMO

Single-material interference filters are obtained from magnetron sputtered alternating layers of WO3 deposited at different pressures. The stop band is investigated with respect to the refractive index contrast and the total number of layers. Some features of rugate filters are also investigated. We show experimentally that a sine-wave index profile modulation can be used to suppress the harmonic stop bands located at odd fractional wavelengths. We also show experimental evidence that sidelobes near the stop band can be attenuated by using a sine-wave index profile that has a variable amplitude.

2.
Sci Adv ; 10(15): eadm7600, 2024 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-38608019

RESUMO

Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developing and regenerating mouse nerves. Our data indicate that neddylation exerts a global influence on the complex transcriptional and posttranscriptional program by simultaneously regulating the expression and function of multiple essential myelination signals, including the master transcription factor EGR2 and the negative regulators c-Jun and Sox2, and inducing global secondary changes in downstream pathways, including the mTOR and YAP/TAZ signaling pathways. This places neddylation as a critical regulator of myelination and delineates the potential pathogenic mechanisms involved in CMT mutations related to neddylation.


Assuntos
Doença de Charcot-Marie-Tooth , Células de Schwann , Animais , Camundongos , Bainha de Mielina/genética , Doença de Charcot-Marie-Tooth/genética , Mutação , Processamento de Proteína Pós-Traducional
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