Detalhe da pesquisa
1.
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Mol Microbiol
; 101(3): 381-93, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073104
2.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
3.
UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.
J Biol Chem
; 288(31): 22576-83, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754276
4.
Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.
ChemMedChem
; 11(18): 1995-2014, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27471138