Detalhe da pesquisa
1.
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506.
Bioorg Med Chem Lett
; 94: 129456, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37633618
2.
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.
J Virol
; 95(18): e0057421, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34191584
3.
Ligand conjugate SAR and enhanced delivery in NHP.
Mol Ther
; 29(10): 2910-2919, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34091052
4.
Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates.
Nature
; 521(7552): 362-5, 2015 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901685
5.
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555628
6.
Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates.
J Infect Dis
; 214(suppl 3): S367-S374, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571900
7.
Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer.
J Med Chem
; 67(2): 1421-1446, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38190324
8.
RNAi-mediated gene silencing in non-human primates.
Nature
; 441(7089): 111-4, 2006 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16565705
9.
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B.
Hepatol Commun
; 6(12): 3457-3472, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36194181
10.
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.
Antiviral Res
; 197: 105211, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34826506
11.
Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study.
Lancet
; 375(9729): 1896-905, 2010 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20511019
12.
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.
Nat Commun
; 12(1): 1222, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619272
13.
Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model.
ACS Infect Dis
; 5(5): 738-749, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30408957
14.
ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection.
ACS Infect Dis
; 5(5): 725-737, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403127
15.
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element.
Antiviral Res
; 149: 191-201, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29133129
16.
Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA.
Nat Microbiol
; 1(10): 16142, 2016 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27670117
17.
Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA.
Sci Transl Med
; 6(250): 250ra116, 2014 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25143366
18.
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.
Mol Ther
; 13(3): 494-505, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16343994
19.
Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference.
J Infect Dis
; 193(12): 1650-7, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16703508