Detalhe da pesquisa
1.
Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors.
Bioorg Med Chem Lett
; 81: 129143, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36669575
2.
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc Natl Acad Sci U S A
; 115(13): 3249-3254, 2018 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29531094
3.
Neutrophil-predominant bullous pemphigoid induced by checkpoint inhibitors: A case series.
J Cutan Pathol
; 47(8): 742-746, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196722
4.
Pemphigus foliaceus in a patient with gastrointestinal stromal tumor treated with adjuvant imatinib mesylate.
Dermatol Online J
; 26(6)2020 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32815695
5.
Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.
J Biol Chem
; 291(4): 1854-1865, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627831
6.
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg Med Chem Lett
; 25(9): 1856-63, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845281
7.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21896751
8.
SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib.
Proc Natl Acad Sci U S A
; 105(14): 5507-12, 2008 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18367669
9.
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
J Med Chem
; 62(3): 1348-1361, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30609350
10.
Overuse of Magnetic Resonance Imaging in the Diagnosis and Treatment of Moderate to Severe Osteoarthritis.
Iowa Orthop J
; 38: 33-37, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104922
11.
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
J Med Chem
; 59(3): 1041-51, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751161
12.
Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-ß immunoreactivity after traumatic brain injury in 3xTG-AD mice.
J Neuropathol Exp Neurol
; 72(5): 396-403, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23584199
13.
Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect.
JAAD Case Rep
; 3(3): 236-239, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28443320
14.
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng Des Sel
; 23(5): 375-84, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20150177
15.
Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure.
J Biol Chem
; 280(2): 1346-53, 2005 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15528182
16.
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
EMBO J
; 23(2): 282-93, 2004 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-14685259