Detalhe da pesquisa
1.
MeDBA: the Metalloenzyme Data Bank and Analysis platform.
Nucleic Acids Res
; 51(D1): D593-D602, 2023 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36243971
2.
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.
BMC Med
; 22(1): 96, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38443977
3.
Characterization of a novel carbapenem-hydrolysing ß-lactamase OXA-1041 in Escherichia coli.
J Antimicrob Chemother
; 78(5): 1288-1294, 2023 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36995982
4.
Organocatalytic Asymmetric Morita-Baylis-Hillman Reaction of Isatins with Vinyl Sulfones.
J Org Chem
; 88(6): 3802-3807, 2023 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36822154
5.
New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies.
Bioorg Chem
; 135: 106487, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36996510
6.
Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib.
Pharmacol Res
; 177: 106050, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34973468
7.
MeCOM: A Method for Comparing Three-Dimensional Metalloenzyme Active Sites.
J Chem Inf Model
; 62(3): 730-739, 2022 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35044164
8.
Design, Synthesis, and Biological Evaluation of New 1H-Imidazole-2-Carboxylic Acid Derivatives as Metallo-ß-Lactamase Inhibitors.
Bioorg Med Chem
; 72: 116993, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36084491
9.
MeLAD: an integrated resource for metalloenzyme-ligand associations.
Bioinformatics
; 36(3): 904-909, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31504189
10.
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-ß-lactamases.
Bioorg Med Chem Lett
; 41: 127956, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744439
11.
Principles and current strategies targeting metallo-ß-lactamase mediated antibacterial resistance.
Med Res Rev
; 40(5): 1558-1592, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32100311
12.
Virtual target screening reveals rosmarinic acid and salvianolic acid A inhibiting metallo- and serine-ß-lactamases.
Bioorg Med Chem Lett
; 28(6): 1037-1042, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29477271
13.
Structure-based discovery of new maternal embryonic leucine zipper kinase inhibitors.
Org Biomol Chem
; 16(9): 1489-1495, 2018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29411820
14.
IFPTarget: A Customized Virtual Target Identification Method Based on Protein-Ligand Interaction Fingerprinting Analyses.
J Chem Inf Model
; 57(7): 1640-1651, 2017 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28661143
15.
19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-ß-Lactamase.
Angew Chem Int Ed Engl
; 56(14): 3862-3866, 2017 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28252254
16.
Synthesis and evaluation of styrylpyran fluorophores for noninvasive detection of cerebral ß-amyloid deposits.
Bioorg Med Chem
; 24(4): 827-34, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26774253
17.
Virtual screening in small molecule discovery for epigenetic targets.
Methods
; 71: 158-66, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25462557
18.
An integrated molecular docking and rescoring method for predicting the sensitivity spectrum of various serine hydrolases to organophosphorus pesticides.
J Sci Food Agric
; 96(6): 2184-92, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26172068
19.
A pyrane based fluorescence probe for noninvasive prediction of cerebral ß-amyloid fibrils.
Bioorg Med Chem Lett
; 25(20): 4472-6, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26346365
20.
SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.
Cell Physiol Biochem
; 32(1): 138-53, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867251