1.
J Org Chem
; 88(17): 12474-12480, 2023 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37585492
RESUMO
We report an efficient radical-based and photocatalyst-free method for the C(sp2)-C(sp3) cross-coupling reaction to synthesize α-aryl ester derivatives. The process starts from a ß-keto ester and an electron-deficient halogenated aryl halide under alkaline conditions to form an electron donor-acceptor complex and is driven by visible light. From the synthetic point of view, this newly established method represents a simple way to access arylpropionic acids from commercially available and cheap starting materials.