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1.
Obstet Gynecol ; 113(2 Pt 1): 276-83, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19155895

RESUMO

OBJECTIVE: To test the equivalency of oral sedation and intravenous sedation for pain control in first-trimester surgical abortion. METHODS: Women undergoing suction curettage at less than 13 weeks of gestation were randomly assigned to oral sedation, 10 mg of oxycodone and 1 mg of lorazepam, or intravenous sedation, 100 micrograms fentanyl and 2 mg midazolam. All patients received 800 mg of preoperative ibuprofen and a 20-mL paracervical block with 1% lidocaine. The primary outcome was intraoperative pain as measured on a 21-point verbal rating scale that had a range from 0 to 100 (0=no pain and 100=worst pain ever) with an equivalence margin for the treatment group comparison of +/-10. RESULTS: Of 130 women, 65 were randomly assigned to oral sedation and 65 to intravenous sedation. The groups differed at baseline by age and preoperative ratings of depression, stress, and anxiety; however, when adjusted for these differences, the primary results were unaffected. Mean intraoperative pain scores, controlling for age and preoperative depression, stress, and anxiety, were 61.2 for oral sedation and 36.3 for intravenous sedation (mean difference 24.9, 95% confidence interval 15.9-33.9). Other findings included no difference in postoperative adverse effects and less satisfaction with pain control with oral sedation compared with intravenous sedation. CONCLUSION: Oral sedation, as studied, is not equivalent to intravenous sedation for pain control during first-trimester surgical abortion. CLINICAL TRIAL REGISTRATION: : ClinicalTrials.gov, www.clinicaltrials.gov, NCT00337792 LEVEL OF EVIDENCE: I.


Assuntos
Aborto Induzido , Anestésicos Intravenosos/uso terapêutico , Sedação Consciente/métodos , Hipnóticos e Sedativos/administração & dosagem , Dor/prevenção & controle , Administração Oral , Adulto , Feminino , Humanos , Medição da Dor , Satisfação do Paciente , Gravidez , Adulto Jovem
2.
Obstet Gynecol ; 109(3): 721-7, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17329526

RESUMO

OBJECTIVE: To examine the association between physical activity and risk of developing urinary incontinence (UI). METHODS: Prospective analysis from the Nurses' Health Study of women aged 54-79 years. Physical activity was reported in 1986 and biennially afterward. To determine stable, long-term activity levels, data were averaged across all questionnaires (bottom quintile: 6.2 metabolic equivalent task hours per week or less; top quintile: more than 28.6 metabolic equivalent task hours per week). From 2000 to 2002, 2,355 cases of incident UI were identified using self-reports of leaking urine. Type of incontinence was determined from questions regarding the circumstances during which leaking occurred. We estimated adjusted odds ratios (ORs) of developing incontinence across quintiles of physical activity levels using logistic regression, controlling for numerous potential confounding factors. RESULTS: Increasing levels of total physical activity were significantly associated with a reduced risk of UI (top versus bottom quintile of metabolic equivalent task hours per week, OR 0.81, 95% confidence interval [CI] 0.71-0.93; P for trend across quintiles <.01). Walking, which constituted approximately half of total physical activity among our participants, was related to 26% lower risk of developing UI (top versus bottom quintile, OR 0.74, 95% CI 0.63-0.88; P for trend across quintiles <.01). Specifically, total physical activity and walking were associated with a significant reduction in stress UI (physical activity: P for trend =.01; walking: P for trend =.01), but neither was related to incidence of urge UI (P for trend =.8 and P for trend =.3, respectively). CONCLUSION: Physical activity was associated with a significant reduction in UI. Results appeared somewhat stronger for stress UI than urge UI. LEVEL OF EVIDENCE: II.


Assuntos
Exercício Físico/fisiologia , Incontinência Urinária/epidemiologia , Idoso , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Razão de Chances , Incontinência Urinária por Estresse/epidemiologia , Incontinência Urinária de Urgência/epidemiologia
3.
Am J Obstet Gynecol ; 197(2): 167.e1-5, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17689637

RESUMO

OBJECTIVE: The objective of the study was to describe changes in urinary incontinence in middle-aged women. STUDY DESIGN: A prospective analysis of 64,650 women aged 36-55 years in the Nurses' Health Study II. Participants reported urine leaking in 2001 and 2003. Two-year incidence and remission proportions were estimated. RESULTS: The 2-year incidence of incontinence was 13.7%. Incidence generally increased through age 50 years and then declined slightly in older women. Among women with incident incontinence at least weekly, the incidence of stress incontinence increased through age 50 years (2-year incidence 1.7%), and the incidence of urge incontinence was stable across age groups (2-year incidence 0.4%). Also, a minority (38%) mentioned leaking to their physician. Complete remission of symptoms occurred in 13.9% of women with incontinence at baseline. CONCLUSION: We found that incontinence occurs frequently in middle-aged women. Yet few women mentioned incontinence to their physicians; thus, it may be important to initiate conversations about urinary symptoms even among younger patients.


Assuntos
Incontinência Urinária/epidemiologia , Adulto , Fatores Etários , Feminino , Humanos , Incidência , Pessoa de Meia-Idade , Estudos Prospectivos
4.
J Am Geriatr Soc ; 53(11): 1851-7, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16274364

RESUMO

OBJECTIVES: To evaluate the association between type 2 diabetes mellitus (DM) and development of urinary incontinence in women. DESIGN: Prospective, observational study. SETTING: The Nurses' Health Study cohort. PARTICIPANTS: Eighty-one thousand eight hundred forty-five women who reported information on urinary function in 1996. MEASUREMENTS: Self-reported, physician-diagnosed DM was ascertained using questionnaire from 1976 to 1996 and confirmed using standard criteria. Self-reported urinary incontinence, defined as leakage at least weekly, was ascertained in 1996 and 2000. Logistic regression models were used to calculate multivariate-adjusted relative risks (RRs) and 95% confidence intervals (CIs) for the relationship between DM (as of 1996) and prevalent and incident incontinence. RESULTS: The risk of prevalent incontinence (multivariate RR=1.28, 95% CI=1.18-1.39) and incident incontinence (multivariate RR=1.21, 95% CI=1.02-1.43) was significantly greater in women with DM than women without. Using a validated severity index, risk of developing severe incontinence was even more substantial in women with DM than in those without (multivariate RR=1.40, 95% CI=1.15-1.71 for leakage enough to wet the underwear; RR=1.97, 95% CI=1.24-3.12 for leakage enough to wet the outer clothing). In addition, risk of incontinence increased with duration of DM (P-trend=.03 for prevalent incontinence; P=.001 for incident incontinence). CONCLUSION: DM independently increases risk of urinary incontinence in women. Because risk of incontinence appeared associated with longer duration of DM, even delaying the onset of DM could have important public health implications.


Assuntos
Diabetes Mellitus Tipo 2/epidemiologia , Enfermeiras e Enfermeiros , Incontinência Urinária/epidemiologia , Adulto , Fatores Etários , Idoso , Índice de Massa Corporal , Estudos de Coortes , Estudos Transversais , Feminino , Inquéritos Epidemiológicos , Humanos , Incidência , Estudos Longitudinais , Pessoa de Meia-Idade , Estudos Prospectivos , Risco , Estatística como Assunto , Estados Unidos
5.
J Eval Clin Pract ; 16(3): 476-83, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20482746

RESUMO

RATIONALE, AIMS AND OBJECTIVES: We sought to use a novel case-selection methodology to identify antenatal or intrapartum risk factors associated with neonatal neurological impairment following non-reassuring fetal heart rate patterns during labour. METHOD: We used a retrospective case-control design with bivariate and multivariate conditional logistic regression. Cases were births in which electronic fetal monitoring (EFM) showed non-reassuring patterns and the infant had neurological disability. Controls were births in which EFM was non-reassuring but the infant was born healthy. We identified 36 cases from among malpractice claims filed with a liability insurer in Massachusetts between 1985 and 2001 and randomly selected 70 controls, matching them to cases by hospital, birth date and gestational age. RESULTS: More cases had maternal antenatal vaginal bleeding (P = 0.004), a prolonged latent phase or protracted dilation during the first stage of labour (P = 0.03), and protracted descent or prolonged second stage (P = 0.01). More cases also had minimal variability on EFM on admission (P = 0.02) and during the second stage (P = 0.02). Multivariate analysis highlighted three significant predictors of neurological injury following complicated labour: antenatal vaginal bleeding (OR = 27.1), prolonged latent phase or protracted dilation in the first stage (OR = 4.0) and EFM showing minimal variability in the first stage (OR = 4.3). CONCLUSION: These promising initial findings suggest that future research into outcomes from complicated labour with non-reassuring heart rate patterns should focus on maternal history of vaginal bleeding, slow labour and minimal variability on EFM.


Assuntos
Frequência Cardíaca Fetal/fisiologia , Imperícia , Doenças do Sistema Nervoso/etiologia , Adolescente , Adulto , Feminino , Monitorização Fetal/métodos , Humanos , Recém-Nascido , Revisão da Utilização de Seguros , Massachusetts , Gravidez , Complicações na Gravidez , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
6.
Urology ; 73(3): 494-8, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19118882

RESUMO

OBJECTIVES: To examine the prevalence of and symptoms associated with painful bladder syndrome (PBS) in a population of older women, utilizing the Nurses' Health Study (NHS) cohort. METHODS: In 2004, NHS participants were asked by mailed questionnaire, "In the past 10 years, have you experienced bladder or pelvic pain associated with urinary symptoms for more than 3 consecutive months?" Women who responded "yes" were sent a detailed supplementary questionnaire. A severity score was calculated according to information about symptoms and bother in the previous 6 months. RESULTS: The PBS screening question was answered by 67,095 participants. A supplemental questionnaire was sent to all 4005 women who answered yes, and 3042 (76%) responded. Symptoms consistent with PBS were reported by 1548 respondents (51%), representing 2.3% of the screened cohort. The prevalence of PBS was 1.7% in those younger than 65 years and increased progressively to 4.0% in women aged 80 years and older (P trend <0.001). Severity, based on both symptoms and bother, was mild in 14.8% of women with PBS, moderate in 29.0%, and severe in 56.2%. CONCLUSIONS: Painful bladder syndrome is a common condition in women. The prevalence of PBS increases with age, and the vast majority of women with PBS have moderate or severe symptoms.


Assuntos
Cistite Intersticial/epidemiologia , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Prevalência , Índice de Gravidade de Doença , Inquéritos e Questionários
7.
J Am Geriatr Soc ; 56(7): 1191-8, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18492035

RESUMO

OBJECTIVES: To examine the epidemiology of urinary incontinence (UI) in older women. DESIGN: Prospective study. SETTING: Nurses' Health Study. PARTICIPANTS: Incidence of UI was determined in 23,792 women aged 54 to 79 without UI at baseline. Progression or remission of UI was determined in 28,813 women with UI at least monthly at baseline. MEASUREMENTS: UI was ascertained according to questionnaires in 2000 and 2002. Rates of incident UI and progression or remission of prevalent UI were calculated. Logistic regression was used to estimate relative risks of UI associated with risk factors. RESULTS: In women with no urine leakage at baseline, 9.2% reported leakage at least monthly after 2 years. For women with leakage at least weekly, the incidence was 3.6%; of these cases, stress UI had the highest incidence, followed by mixed and urge UI. Relationships between UI and age differed for stress UI, which decreased with age (relative risk (RR)=0.63, 95% confidence interval (CI)=0.43-0.92 for aged 70-79 vs 54-59), and urge and mixed UI, which increased with age (RR=2.28, 95% CI=1.09-4.75 and RR=2.11, 95% CI=1.24-3.61, respectively). For prevalent UI in 2000, 32.1% of subjects with leakage once a month progressed to leakage at least once a week over follow-up. Only 8.9% with frequent leakage in 2000 reported improvement to monthly leakage or less, with 2.0% having complete remission. CONCLUSION: The incidence of UI is high in older women, and progression from occasional to frequent leaking is common. Urge UI, for which there are limited effective treatments, increases with age, thus research on UI prevention in older women is particularly important.


Assuntos
Incontinência Urinária/epidemiologia , Idoso , Estudos de Coortes , Feminino , Humanos , Incidência , Modelos Logísticos , Pessoa de Meia-Idade , Pesquisa em Enfermagem , Índice de Gravidade de Doença , Inquéritos e Questionários , Estados Unidos/epidemiologia , Incontinência Urinária/classificação
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