Detalhe da pesquisa
1.
AI-Driven Discovery of SARS-CoV-2 Main Protease Fragment-like Inhibitors with Antiviral Activity In Vitro.
J Chem Inf Model
; 63(9): 2866-2880, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37058135
2.
Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification.
Bioorg Med Chem
; 95: 117498, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37857256
3.
Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Proc Natl Acad Sci U S A
; 114(32): 8544-8549, 2017 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28739903
4.
Structural insight into the biogenesis of ß-barrel membrane proteins.
Nature
; 501(7467): 385-90, 2013 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23995689
5.
Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.
J Biol Chem
; 290(46): 27736-48, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26370075
6.
Structural engineering of a phage lysin that targets gram-negative pathogens.
Proc Natl Acad Sci U S A
; 109(25): 9857-62, 2012 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22679291
7.
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein.
RSC Chem Biol
; 5(2): 117-130, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38333195
8.
Cyclic ß2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.
Bull Chem Soc Jpn
; 97(5): uoae018, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38828441
9.
Using high-throughput in situ plate screening to evaluate the effect of dehydration on protein crystals.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 5): 920-3, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23633603
10.
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.
J Med Chem
; 66(4): 2663-2680, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757959
11.
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease.
Nat Chem
; 15(7): 998-1005, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37217786
12.
Accelerating drug target inhibitor discovery with a deep generative foundation model.
Sci Adv
; 9(25): eadg7865, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37343087
13.
Using a bacteriocin structure to engineer a phage lysin that targets Yersinia pestis.
Biochem Soc Trans
; 40(6): 1503-6, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23176506
14.
East Coast fever, a neglected tropical disease with an outdated vaccine approach?
Trends Parasitol
; 38(11): 930-932, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36041933
15.
xia2.multiplex: a multi-crystal data-analysis pipeline.
Acta Crystallogr D Struct Biol
; 78(Pt 6): 752-769, 2022 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647922
16.
Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine.
J Med Chem
; 65(11): 7682-7696, 2022 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35549342
17.
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS-CoV-2 Papain-Like Protease.
ChemMedChem
; 17(9): e202200016, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35085423
18.
The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif.
PLoS One
; 16(10): e0256070, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34653190
19.
Mass spectrometry reveals potential of ß-lactams as SARS-CoV-2 Mpro inhibitors.
Chem Commun (Camb)
; 57(12): 1430-1433, 2021 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33462575
20.
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor.
Cell Chem Biol
; 28(12): 1795-1806.e5, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34174194