Detalhe da pesquisa
1.
Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate.
Biochemistry
; 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306231
2.
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates.
Am J Hum Genet
; 104(4): 625-637, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30879639
3.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
4.
Discovery of a novel series of 4-quinolone JNK inhibitors.
Bioorg Med Chem Lett
; 22(24): 7381-7, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142618
5.
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia.
Nat Commun
; 11(1): 5339, 2020 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33087718
6.
Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia.
EBioMedicine
; 45: 519-528, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31303505
7.
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria.
Nat Med
; 24(12): 1899-1909, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297912
8.
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia.
Cell Rep
; 21(12): 3548-3558, 2017 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29262333
9.
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J Med Chem
; 60(22): 9184-9204, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29120638
10.
Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.
Acta Crystallogr F Struct Biol Commun
; 71(Pt 5): 566-71, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25945710
11.
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia.
Cell Rep
; 24(9): 2520, 2018 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30157442
12.
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
J Med Chem
; 56(20): 7788-803, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24093940
13.
Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain.
J Med Chem
; 56(20): 7772-87, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24083782
14.
Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.
ACS Med Chem Lett
; 3(9): 764-8, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900545
15.
The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: an intermediate conformation with T-state and R-state features.
Proteins
; 63(4): 1123-6, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16523484