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1.
Optom Vis Sci ; 90(5): 475-81, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23563444

RESUMO

PURPOSE: We conducted a pilot randomized clinical trial of office-based active vision therapy for the treatment of childhood amblyopia to determine the feasibility of conducting a full-scale randomized clinical trial. METHODS: A training and certification program and manual of procedures were developed to certify therapists to administer a standardized vision therapy program in ophthalmology and optometry offices consisting of weekly visits for 16 weeks. Nineteen children, aged 7 to less than 13 years, with amblyopia (20/40-20/100) were randomly assigned to receive either 2 hours of daily patching with active vision therapy or 2 hours of daily patching with placebo vision therapy. RESULTS: Therapists in diverse practice settings were successfully trained and certified to perform standardized vision therapy in strict adherence with protocol. Subjects completed 85% of required weekly in-office vision therapy visits. Eligibility criteria based on age, visual acuity, and stereoacuity, designed to identify children able to complete a standardized vision therapy program and judged likely to benefit from this treatment, led to a high proportion of screened subjects being judged ineligible, resulting in insufficient recruitment. There were difficulties in retrieving adherence data for the computerized home therapy procedures. CONCLUSIONS: This study demonstrated that a 16-week treatment trial of vision therapy was feasible with respect to maintaining protocol adherence; however, recruitment under the proposed eligibility criteria, necessitated by the standardized approach to vision therapy, was not successful. A randomized clinical trial of in-office vision therapy for the treatment of amblyopia would require broadening of the eligibility criteria and improved methods to gather objective data regarding the home therapy. A more flexible approach that customizes vision therapy based on subject age, visual acuity, and stereopsis might be required to allow enrollment of a broader group of subjects.


Assuntos
Ambliopia/terapia , Percepção de Profundidade/fisiologia , Óculos , Privação Sensorial , Acuidade Visual , Adolescente , Ambliopia/fisiopatologia , Criança , Estudos de Viabilidade , Seguimentos , Humanos , Resultado do Tratamento
2.
Invest Ophthalmol Vis Sci ; 64(14): 17, 2023 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-37962529

RESUMO

Purpose: Uncorrected hyperopic children must overcome an apparent conflict between accommodation and vergence demands to focus and align their retinal images. This study tested hypotheses about simultaneous accommodation and vergence performance of young hyperopes to gain insight into ocular motor strategies used to maintain eye alignment. Methods: Simultaneous eccentric photorefraction and Purkinje image tracking were used to assess accommodative and vergence responses of 26 adult emmetropes (AE) and 94 children (0-13 years) viewing cartoons. Children were habitually uncorrected (CU) (spherical equivalent refractive error [SE] -0.5 to +4 D), corrected and aligned (CCA), or corrected with a history of refractive esotropia (CCS). Accommodative and vergence accuracy, dissociated heterophoria, and vergence/accommodation ratios in the absence of retinal disparity cues were measured for 33- and 80-cm viewing distances. Results: In binocular viewing, median accommodative lags for 33 cm were 1.0 D (AE), 1.33 D (CU), 1.25 D (CCA), and 1.0 D (CCS). Median exophorias at 80 and 33 cm were 1.2 and 4.5 pd (AE), 0.8 and 2.5 pd (CU), and 0 and 1.2 pd (CCA), respectively. Without disparity cues, most response vergence/accommodation ratios were between 1 and 2 meter angle/D (∼5-10 pd/D) (69% of AE, 44% of CU, 60% of CCA, and 50% of CCS). Conclusions: Despite apparent conflict in motor coupling, uncorrected hyperopes were typically exophoric and achieved adultlike accuracy of both vergence and accommodation simultaneously, indicating ability to compensate for conflicting demands rather than bias to accurate vergence while tolerating inaccurate accommodation. Large lags and esophoria are therefore atypical. This analysis provides normative guidelines for clinicians and a deeper mechanistic understanding of how hyperopes avoid strabismus.


Assuntos
Esotropia , Exotropia , Hiperopia , Estrabismo , Adulto , Criança , Humanos , Acomodação Ocular , Sinais (Psicologia)
3.
J AAPOS ; 25(2): 87.e1-87.e6, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33905837

RESUMO

BACKGROUND: The effectiveness of amblyopia therapy can be limited by poor adherence. Dichoptic therapies are a new approach, but recent trials have demonstrated difficulty maintaining high adherence over extended periods of at-home treatment. We evaluated the efficacy and adherence of Luminopia One-a dichoptic treatment that applies therapeutic modifications to streaming content chosen by the patient. METHODS: This single-arm, multicenter prospective pilot study enrolled children aged 4-12 with anisometropic, strabismic, or mixed amblyopia at 10 pediatric ophthalmic and optometric practices across the United States. The therapeutic was prescribed for 1 hour/day, 6 days/week for 12 weeks of at-home use. The primary endpoint was best-corrected visual acuity (BCVA) at the 12-week follow-up visit. RESULTS: In total, 90 participants (mean age, 6.7 ± 2.0 years) were enrolled, and 73/90 participants (81%) had prior treatment beyond refractive correction. For those who completed the 12-week visit, mean amblyopic eye BCVA improved from 0.50 logMAR to 0.35 logMAR (1.5 logMAR lines; 95% CI, 1.2-1.8 lines; P < 0.0001). Mean stereoacuity improved by 0.28 log arcsec (95% CI, 0.14-0.42 log arcsec; P < 0.0001). Median adherence was 86% (interquartile range, 70%-97%). CONCLUSIONS: In our study cohort, adherence over the 12-week study period was high, and participants demonstrated clinically and statistically significant improvements in visual acuity and stereoacuity.


Assuntos
Ambliopia , Ambliopia/terapia , Criança , Pré-Escolar , Seguimentos , Humanos , Projetos Piloto , Estudos Prospectivos , Privação Sensorial , Resultado do Tratamento , Acuidade Visual
4.
Optom Vis Sci ; 86(3): 233-43, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19214130

RESUMO

PURPOSE: To evaluate two clinical procedures, Monocular Estimate Method (MEM) and Nott retinoscopy, for detecting accommodative lags 1.00 diopter (D) or greater in children as identified by an open-field autorefractor. METHODS: One hundred sixty-eight children 8 to <12 years old with low myopia, normal visual acuity, and no strabismus participated as part of an ancillary study within the screening process for a randomized trial. Accommodative response to a 3.00 D demand was first assessed by MEM and Nott retinoscopy, viewing binocularly with spherocylindrical refractive error corrected, with testing order randomized and each performed by a different masked examiner. The response was then determined viewing monocularly with spherical equivalent refractive error corrected, using an open-field autorefractor, which was the gold standard used for eligibility for the clinical trial. Sensitivity and specificity for accommodative lags of 1.00 D or more were calculated for each retinoscopy method compared to the autorefractor. RESULTS: One hundred sixteen (69%) of the 168 children had accommodative lag of 1.00 D or more by autorefraction. MEM identified 66 children identified by autorefraction for a sensitivity of 57% (95% CI = 47 to 66%) and a specificity of 63% (95% CI = 49 to 76%). Nott retinoscopy identified 35 children for a sensitivity of 30% (95% CI = 22 to 39%) and a specificity of 81% (95% CI = 67 to 90%). Analysis of receiver operating characteristic curves constructed for MEM and for Nott retinoscopy failed to reveal alternate cut points that would improve the combination of sensitivity and specificity for identifying accommodative lag > or =1.00 D as defined by autorefraction. CONCLUSIONS: Neither MEM nor Nott retinoscopy provided adequate sensitivity and specificity to identify myopic children with accommodative lag > or =1.00 D as determined by autorefraction. A variety of methodological differences between the techniques may contribute to the modest to poor agreement.


Assuntos
Acomodação Ocular , Miopia/diagnóstico , Miopia/fisiopatologia , Refração Ocular , Retinoscopia/métodos , Criança , Estudos de Coortes , Feminino , Humanos , Masculino , Curva ROC , Sensibilidade e Especificidade , Fatores de Tempo
5.
Arch Ophthalmol ; 123(4): 437-47, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15824215

RESUMO

OBJECTIVE: To evaluate the effectiveness of treatment of amblyopia in children aged 7 to 17 years. METHODS: At 49 clinical sites, 507 patients with amblyopic eye visual acuity ranging from 20/40 to 20/400 were provided with optimal optical correction and then randomized to a treatment group (2-6 hours per day of prescribed patching combined with near visual activities for all patients plus atropine sulfate for children aged 7 to 12 years) or an optical correction group (optical correction alone). Patients whose amblyopic eye acuity improved 10 or more letters (> or =2 lines) by 24 weeks were considered responders. RESULTS: In the 7- to 12-year-olds (n = 404), 53% of the treatment group were responders compared with 25% of the optical correction group (P<.001). In the 13- to 17-year-olds (n = 103), the responder rates were 25% and 23%, respectively, overall (adjusted P = .22) but 47% and 20%, respectively, among patients not previously treated with patching and/or atropine for amblyopia (adjusted P = .03). Most patients, including responders, were left with a residual visual acuity deficit. CONCLUSIONS: Amblyopia improves with optical correction alone in about one fourth of patients aged 7 to 17 years, although most patients who are initially treated with optical correction alone will require additional treatment for amblyopia. For patients aged 7 to 12 years, prescribing 2 to 6 hours per day of patching with near visual activities and atropine can improve visual acuity even if the amblyopia has been previously treated. For patients 13 to 17 years, prescribing patching 2 to 6 hours per day with near visual activities may improve visual acuity when amblyopia has not been previously treated but appears to be of little benefit if amblyopia was previously treated with patching. We do not yet know whether visual acuity improvement will be sustained once treatment is discontinued; therefore, conclusions regarding the long-term benefit of treatment and the development of treatment recommendations for amblyopia in children 7 years and older await the results of a follow-up study we are conducting on the patients who responded to treatment.


Assuntos
Ambliopia/terapia , Atropina/uso terapêutico , Óculos , Midriáticos/uso terapêutico , Privação Sensorial , Adolescente , Atropina/administração & dosagem , Atropina/efeitos adversos , Criança , Terapia Combinada , Feminino , Seguimentos , Humanos , Masculino , Midriáticos/administração & dosagem , Midriáticos/efeitos adversos , Projetos Piloto , Leitura , Resultado do Tratamento , Jogos de Vídeo , Visão Binocular , Acuidade Visual/fisiologia
6.
J AAPOS ; 9(2): 129-36, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15838439

RESUMO

BACKGROUND: To plan a future randomized clinical trial, we conducted a pilot study to determine whether children randomized to near or non-near activities would perform prescribed activities. A secondary aim was to obtain a preliminary estimate of the effect of near versus non-near activities on amblyopic eye visual acuity, when combined with 2 hours of daily patching. METHODS: Sixty-four children, 3 to less than 7 years of age, with anisometropic, strabismic, or combined amblyopia (20/40 to 20/400) were randomly assigned to receive either 2 hours of daily patching with near activities or 2 hours of daily patching without near activities. Parents completed daily calendars for 4 weeks recording the activities performed while patched and received a weekly telephone call in which they were asked to describe the activities performed during the previous 2 hours of patching. Visual acuity was assessed at 4 weeks. RESULTS: The children assigned to near visual activities performed more near activities than those assigned to non-near activities (by calendars, mean 1.6 +/- 0.5 hours versus 0.2 +/- 0.2 hours daily, P < 0.001; by telephone interviews, 1.6 +/- 0.4 hours versus 0.4 +/- 0.5 hours daily, P < 0.001). After 4 weeks of treatment, there was a suggestion of greater improvement in amblyopic eye visual acuity in those assigned to near visual activities (mean 2.6 lines versus 1.6 lines, P = 0.07). The treatment group difference in visual acuity was present for patients with severe amblyopia but not moderate amblyopia. CONCLUSIONS: Children patched and instructed to perform near activities for amblyopia spent more time performing those near activities than children who were instructed to perform non-near activities. Our results suggest that performing near activities while patched may be beneficial in treating amblyopia. Based on our data, a formal randomized amblyopia treatment trial of patching with and without near activities is both feasible and desirable.


Assuntos
Atividades Cotidianas , Ambliopia/terapia , Bandagens , Percepção de Distância/fisiologia , Privação Sensorial , Acuidade Visual/fisiologia , Ambliopia/fisiopatologia , Criança , Pré-Escolar , Seguimentos , Humanos , Entrevistas como Assunto/métodos , Cooperação do Paciente , Projetos Piloto , Índice de Gravidade de Doença , Inquéritos e Questionários , Fatores de Tempo , Resultado do Tratamento
7.
Optometry ; 76(10): 593-9, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16230275

RESUMO

BACKGROUND: The use of a phoropter for measuring phorias and vergences in children is common in the optometric profession. For young children, the use of the phoropter can be confusing, making it difficult to obtain accurate measurements. Free space testing allows for direct observation of the eyes in a natural environment and is easier for children to understand the directions. The normal values for phorias and vergences used with children are derived from testing with a phoropter or free space measurements with mostly adult patients. METHODS: The Benton-IU Project was a large multidisciplinary study of factors affecting school performance conducted by the Indiana University School of Optometry and the Indiana University Department of Speech and Hearing with the cooperation of the Benton Community School Corporation (Benton County, Indiana). This project allowed the authors to obtain data on modified Thorington phorias and prism bar vergences from a nonselected group of first and fourth graders as part of an eye/vision examination. RESULTS: In this report, central tendency and variability statistics for modified Thorington and prism bar vergences are reported based on the data from the Benton-IU Study. CONCLUSION: The data presented in this report can be used by optometrists when deciding if the patient's phorias and vergences are within normal limits for children in the first through fourth grades.


Assuntos
Acomodação Ocular , Movimentos Oculares , Estrabismo/diagnóstico , Criança , Cognição , Dislexia/diagnóstico , Humanos , Fenômenos Fisiológicos Oculares , Leitura , Valores de Referência , Testes Visuais/métodos , Redação
8.
Invest Ophthalmol Vis Sci ; 53(1): 143-9, 2012 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-22125280

RESUMO

PURPOSE: To determine the accommodative accuracy of infants and young children before they had had any form of clinical intervention or treatment, in an attempt to determine the difference between 'normal' and 'abnormal' visual experience for these individuals. METHODS: Nott retinoscopy was performed on 111 subjects in binocular viewing conditions at a viewing distance of 50 cm. The target was a naturalistic cartoon image with a broadband spatial frequency amplitude spectrum. RESULTS: Accommodative accuracy was not related to age (4-90 months). In the group found to have no apparent clinical abnormality (n = 71), the mean lag in the more hyperopic meridian of the least ametropic eye was 0.34 diopters (D). When considering the group as a whole, those with less than approximately 4 D of hyperopia demonstrated similar lags, while those with higher hyperopia, amblyopia, or strabismus had more variable lags. An ROC analysis designed to detect hyperopia >5 D in any meridian, amblyopia and/or strabismus had an area under the curve of 0.90 (95% confidence interval [CI], 0.82 to 0.95), and for a lag criterion of 1.3 D had a sensitivity of 83.3% and a specificity of 96.5%. CONCLUSIONS: These data from a relatively small but broad sampling of age and clinical status suggest that clinically normal young infants and children with low amounts of hyperopia have similar lags of accommodation from the first few months after birth. Subjects with greater than 4 D of hyperopia, or amblyopia or strabismus, have more variable lags and therefore evidence of abnormal visual experience.


Assuntos
Acomodação Ocular/fisiologia , Ambliopia/fisiopatologia , Hiperopia/fisiopatologia , Estrabismo/fisiopatologia , Ambliopia/terapia , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Masculino , Retinoscopia , Estrabismo/terapia , Visão Binocular/fisiologia
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