Detalhe da pesquisa
1.
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
J Biol Chem
; 293(35): 13750-13765, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945974
2.
Protein kinase profiling assays: a technology review.
Drug Discov Today Technol
; 18: 1-8, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26723886
3.
A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
J Biol Chem
; 288(39): 28068-77, 2013 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23935097
4.
Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors.
Bioorg Med Chem Lett
; 24(4): 1116-21, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24461299
5.
Preface.
Drug Discov Today Technol
; 18: 50-1, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26723892
6.
Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
J Med Chem
; 63(17): 10061-10085, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787083
7.
Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs.
Drug Des Devel Ther
; 11: 1369-1382, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28496307
8.
Chemical microarray: a new tool for drug screening and discovery.
Drug Discov Today
; 11(13-14): 661-8, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16793536
9.
Microarrays for the functional analysis of the chemical-kinase interactome.
J Biomol Screen
; 11(1): 48-56, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16314406
10.
Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor.
J Exp Pharmacol
; 8: 11-9, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27574472
11.
Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases.
Cell Rep
; 14(4): 772-781, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26776524
12.
Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling.
Assay Drug Dev Technol
; 3(2): 177-87, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15871692
13.
Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.
Assay Drug Dev Technol
; 13(4): 221-34, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26065558
14.
Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors.
J Med Chem
; 58(1): 466-79, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25478866
15.
Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.
Chem Biol
; 22(2): 273-84, 2015 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25699604
16.
Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis.
Drug Des Devel Ther
; 8: 583-600, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24920883
17.
Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.
Mol Cancer Ther
; 13(1): 221-9, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24170769
18.
Development of multiple cell-based assays for the detection of histone H3 Lys27 trimethylation (H3K27me3).
Assay Drug Dev Technol
; 11(7): 449-56, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23992119
19.
Assay development for histone methyltransferases.
Assay Drug Dev Technol
; 11(4): 227-36, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23557020
20.
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.
Mol Cancer Ther
; 12(5): 610-20, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625935