Detalhe da pesquisa
1.
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions.
Proc Natl Acad Sci U S A
; 121(8): e2314914121, 2024 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346202
2.
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force.
Proc Natl Acad Sci U S A
; 120(5): e2207615120, 2023 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696446
3.
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.
Proc Natl Acad Sci U S A
; 120(23): e2221244120, 2023 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37252999
4.
Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle.
Circ Res
; 133(5): 430-443, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470183
5.
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin.
Proc Natl Acad Sci U S A
; 119(8)2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177471
6.
Titin force in muscle cells alters lattice order, thick and thin filament protein formation.
Proc Natl Acad Sci U S A
; 119(48): e2209441119, 2022 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36409887
7.
Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle.
J Physiol
; 602(12): 2751-2762, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38695322
8.
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension.
Circulation
; 147(25): 1919-1932, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37194598
9.
GSK-3ß Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation.
Circ Res
; 130(6): 871-886, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35168370
10.
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains.
EMBO Rep
; 23(8): e55056, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35762418
11.
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
Proc Natl Acad Sci U S A
; 118(17)2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33888578
12.
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium.
Circ Res
; 129(6): 617-630, 2021 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34365814
13.
The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms.
Proc Natl Acad Sci U S A
; 117(22): 11865-11874, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32444484
14.
Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.
Int J Mol Sci
; 24(19)2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37834023
15.
Myofibril orientation as a metric for characterizing heart disease.
Biophys J
; 121(4): 565-574, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35032456
16.
Thick filament activation is different in fast- and slow-twitch skeletal muscle.
J Physiol
; 600(24): 5247-5266, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342015
17.
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.
Proc Natl Acad Sci U S A
; 116(23): 11502-11507, 2019 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31110001
18.
Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease.
Int J Mol Sci
; 23(6)2022 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35328477
19.
EMD-57033 Augments the Contractility in Porcine Myocardium by Promoting the Activation of Myosin in Thick Filaments.
Int J Mol Sci
; 23(23)2022 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36498844
20.
MgADP Promotes Myosin Head Movement toward Actin at Low [Ca2+] to Increase Force Production and Ca2+-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips.
Int J Mol Sci
; 23(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499408