Detalhe da pesquisa
1.
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc Natl Acad Sci U S A
; 121(6): e2317756121, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38300868
2.
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov
; 14(2): 240-257, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916956
3.
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes.
J Med Chem
; 66(14): 9297-9312, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403870
4.
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation.
Cancer Discov
; 13(10): 2150-2165, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712569
5.
Corrigendum: The promise and peril of chemical probes.
Nat Chem Biol
; 11(11): 887, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26485080
6.
The promise and peril of chemical probes.
Nat Chem Biol
; 11(8): 536-41, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26196764
7.
Principles of Kinase Allosteric Inhibition and Pocket Validation.
J Med Chem
; 65(7): 5288-5299, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35312319
8.
Structure-guided expansion of kinase fragment libraries driven by support vector machine models.
Biochim Biophys Acta
; 1804(3): 642-52, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20005305
9.
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
J Med Chem
; 64(7): 3697-3706, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33591753
10.
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
ACS Med Chem Lett
; 9(7): 612-617, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034588
11.
Beyond PAINs: Chemotype Sensitivity of Protein Methyltransferases in Screens.
ACS Med Chem Lett
; 7(2): 156-61, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985291
12.
Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth.
Mol Cancer Ther
; 15(10): 2344-2356, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27439478
13.
Novel antiproliferative antitumor agents.
Curr Opin Drug Discov Devel
; 8(5): 613-8, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16159023
14.
Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.
J Med Chem
; 47(22): 5367-80, 2004 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15481975
15.
Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies.
Chem Rev
; 97(5): 1281-1302, 1997 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-11851452
16.
Silylacetic Esters: Enolate Reactions and Polyol Preparation.
J Org Chem
; 63(8): 2761-2764, 1998 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-11672153
17.
Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.
J Biol Chem
; 280(19): 19298-305, 2005 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15737997
18.
Acyl sulfonamide anti-proliferatives. Part 2: activity of heterocyclic sulfonamide derivatives.
Bioorg Med Chem Lett
; 15(3): 617-20, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664824
19.
Computational investigation of the role of fluoride in Tamao oxidations.
Chemistry
; 8(21): 5043-8, 2002 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12489539
20.
Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives.
J Am Chem Soc
; 125(9): 2370-1, 2003 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12603106