Detalhe da pesquisa
1.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother
; 66(6): e0013222, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35607978
2.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
3.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433953
4.
An efficient synthetic route for preparation of antimycobacterial wollamides and evaluation of their in vitro and in vivo efficacy.
Bioorg Med Chem Lett
; 28(17): 2899-2905, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30031620
5.
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Bioorg Med Chem
; 26(11): 2996-3005, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779669
6.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
7.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Proc Natl Acad Sci U S A
; 111(50): E5455-62, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453091
8.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
9.
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.
Antimicrob Agents Chemother
; 60(6): 3669-75, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044554
10.
Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease.
J Med Chem
; 66(2): 1522-1542, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36626662
11.
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp.
Elife
; 112022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35289746
12.
Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen.
Antimicrob Agents Chemother
; 55(12): 5740-5, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21968362
13.
Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Antimicrob Agents Chemother
; 55(6): 2612-22, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21422215
14.
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
J Med Chem
; 64(13): 9404-9430, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34156862
15.
Synthesis and Evaluation of Antimycobacterial and Antiplasmodial Activities of Hirsutellide A and Its Analogues.
ACS Omega
; 5(24): 14451-14460, 2020 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32596583
16.
Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors.
J Med Chem
; 63(17): 9912-9927, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786222
17.
Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics.
J Med Chem
; 63(5): 2527-2546, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31670951
18.
Exploring the SAR of the ß-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
ACS Infect Dis
; 6(5): 1098-1109, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196311
19.
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis.
J Med Chem
; 63(2): 756-783, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31846577
20.
Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.
RSC Med Chem
; 11(8): 950-959, 2020 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479690