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BACKGROUND: Identifying potential factors correlated with the sustained presence of antibodies in plasma may facilitate improved retrospective diagnoses and aid in the appraisal of pertinent vaccination strategies for various demographic groups. The main objective was to describe the persistence of anti-spike IgG one year after diagnosis in children and analyse its levels in relation to epidemiological and clinical variables. METHODS: A prospective, longitudinal, observational study was conducted in a university reference hospital in the Metropolitan Region of Barcelona (Spain) (March 2020-May 2021). This study included patients under 18 years of age with SARS-CoV-2 infection (positive PCR or antigen tests for SARS-CoV-2). Clinical and serological follow-up one year after infection was performed. RESULTS: We included 102 patients with a median age of 8.8 years. Anti-spike IgG was positive in 98/102 (96%) 12 months after the infection. There were higher anti-spike IgG levels were noted in patients younger than 2 years (p = 0.034) and those with pneumonia (p < 0.001). A positive and significant correlation was observed between C-reactive protein at diagnosis and anti-spike IgG titre one-year after diagnosis (p = 0.027). CONCLUSION: Anti-SARS-CoV-2 IgG antibodies were detected in almost all paediatric patients one year after infection. We also observed a positive correlation between virus-specific IgG antibody titres with SARS-CoV-2 clinical phenotype (pneumonia) and age (under 2 years old).
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BACKGROUND: The objective of this study is to analyze the transplacental transmission of SARS-CoV-2 antibodies, their persistence in newborns, the factors that may influence this transmission, and the protection these antibodies confer over time. METHODS: This prospective cohort was conducted in a tertiary pediatric hospital in the Barcelona Metropolitan Region, Spain. It included neonates born to mothers who had SARS-CoV-2 infection during pregnancy or delivery between August 2020 and January 2022. We followed the recruited children for at least six months, and blood tests were performed to determine the presence of SARS-CoV-2 antibodies. RESULTS: A total of 101 children were recruited. Among the serologies performed on children under three months of age, 44/82 were positive (53.7%). Newborns whose mothers presented more severe disease exhibited higher seropositivity odds (coefficient 9.747; p = 0.002). There were increased preterm deliveries when maternal infection occurred closer to the time of delivery. No severe SARS-CoV-2 infections were detected in children during the follow-up. CONCLUSIONS: Slightly more than half of the SARS-CoV-2 serologies performed in the first three months were positive. This appears to confer protection during early childhood. The severity of maternal infection is the most significant factor influencing the transmission of antibodies in children born to unvaccinated mothers.
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OBJECTIVE: The complexity of consultations for child and adolescent sexual abuse (CSA), added to the high service pressure in Emergency Department (ED), makes legal proceedings to be prioritized over medical action, and security incidents may appear. Our objective was to evaluate the impact of a checklist for the management of acute CSA in ED, assessing the number and type of security incidents. METHODS: A single-centre, descriptive-observational study was conducted between 2018 in ED. Clinical, epidemiological and follow-up data were collected in those patients younger than 18 that were reported as acute CSA suspicions. Incidents about clinical history, procedures and medication were analyzed. The sample were divided in two groups in relation the use of checklist (Group1: January-May and Group 2: June-December). RESULTS: Thirty-two patients were included: 13 Group 1, 19 Group 2. In 25 (78.1%) incidents were detected from the clinical history, in 20 (56.3%) from procedures and in 5 (15.5%) from medication. One-hundred by one-hundred clinical history incidents and 100% procedural incidents were observed in Group 1 vs 63.2% and 36.8% in Group 2 (p=0.025 y p=0.007) and 30.8% of medication incidents in Group 1 vs 5.3% in Group 2 (p=0.051). CONCLUSIONS: The implementation of the checklist has led to an improvement in the medical care of patients with acute CSA with a decrease in security incident.
OBJETIVO: La complejidad de las consultas por abuso sexual infantojuvenil (ASI) sumada a la presión asistencial en el servicio de urgencias (SU) hace que se prioricen las diligencias legales a la actuación médica pudiendo aparecer incidentes de seguridad. El objetivo de este trabajo fue evaluar el impacto de un checklist para el manejo de ASI en el SU valorando el número y tipo de incidentes de seguridad. METODOS: Estudio unicéntrico, descriptivo-observacional. Se recogieron datos clínicos, epidemiológicos y de seguimiento de todos los pacientes menores de 18 años que fueron atendidos en el SU por sospecha de ASI agudo durante 2018. Se analizaron los incidentes de la historia clínica, procedimientos y medicación. La muestra se dividió en dos grupos en relación al inicio del uso del checklist en el SU (Grupo: Enero-mayo y Grupo 2: junio-diciembre). RESULTADOS: Se incluyeron 32 casos: 13 Grupo 1, 19 Grupo 2. En 25 (78,1%) se detectaron incidentes de historia clínica, en 20 (56,3%) de procedimiento y en 5 (15,5%) de medicación. Se observaron 100% de incidentes tanto de historia clínica como de procedimiento en el Grupo 1 vs 63,2% y 36,8% respectivamente en el Grupo 2 (p=0,025 y p=0,007) y 30,8% de medicación en Grupo 1 vs 5,3% en Grupo 2 (p=0,051). CONCLUSIONES: La implantación del checklist ha supuesto una mejora en la atención médica de los pacientes con ASI agudo, con una disminución de los incidentes de seguridad.