Detalhe da pesquisa
1.
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Bioorg Med Chem Lett
; 68: 128764, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504513
2.
Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction.
J Cell Physiol
; 234(7): 10138-10147, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30417369
3.
Mechanism of action of camphoryl-benzene sulfonamide derivative on glucose uptake in adipose tissue.
J Cell Biochem
; 119(6): 4408-4419, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29130561
4.
Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.
Bioorg Med Chem
; 26(21): 5742-5750, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389409
5.
Solid lipid nanoparticles improve octyl gallate antimetastatic activity and ameliorate its renal and hepatic toxic effects.
Anticancer Drugs
; 28(9): 977-988, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28746057
6.
Incretinomimetic and Insulinomimetic Effect of (2E)-N'-(1'-Naphthyl)-3,4,5-Trimethoxybenzohydrazide for Glycemic Homeostasis.
J Cell Biochem
; 117(5): 1199-209, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26447772
7.
Investigation of cellular mechanisms involved in apoptosis induced by a synthetic naphthylchalcone in acute leukemia cell lines.
Anticancer Drugs
; 27(8): 738-47, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27337110
8.
Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum.
J Enzyme Inhib Med Chem
; 30(2): 299-307, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24964346
9.
Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles.
An Acad Bras Cienc
; 87(2 Suppl): 1421-34, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26247149
10.
Activity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita.
Exp Parasitol
; 135(4): 661-8, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24140596
11.
Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model.
Invest New Drugs
; 30(3): 870-9, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21221709
12.
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
Bioorg Med Chem Lett
; 22(1): 225-30, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169259
13.
Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: synthesis, biological evaluation, molecular modeling and structure-activity relationship (SAR).
Bioorg Med Chem
; 19(16): 5046-52, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21757358
14.
Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition.
Eur J Pharm Sci
; 159: 105731, 2021 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33493668
15.
Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats.
J Med Chem
; 64(4): 1904-1929, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33626870
16.
Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.
Bioorg Med Chem
; 18(11): 3783-9, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20462762
17.
Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin.
Neurobiol Stress
; 13: 100226, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32478146
18.
The serotonergic and alpha-1 adrenergic receptor modulator ACH-000029 ameliorates anxiety-like behavior in a post-traumatic stress disorder model.
Neuropharmacology
; 164: 107912, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31843397
19.
Preclinical characterization of ACH-000029, a novel anxiolytic compound acting on serotonergic and alpha-adrenergic receptors.
Prog Neuropsychopharmacol Biol Psychiatry
; 95: 109707, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31330215
20.
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
ACS Med Chem Lett
; 10(9): 1266-1271, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531195