Detalhe da pesquisa
1.
Membrane phosphoinositides regulate GPCR-ß-arrestin complex assembly and dynamics.
Cell
; 185(24): 4560-4573.e19, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36368322
2.
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.
Cell
; 183(7): 1813-1825.e18, 2020 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33296703
3.
Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling.
Cell
; 161(5): 1101-1111, 2015 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25981665
4.
Structure of the neurotensin receptor 1 in complex with ß-arrestin 1.
Nature
; 579(7798): 303-308, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31945771
5.
Catalytic activation of ß-arrestin by GPCRs.
Nature
; 557(7705): 381-386, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29720660
6.
Single-molecule analysis of ligand efficacy in ß2AR-G-protein activation.
Nature
; 547(7661): 68-73, 2017 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28607487
7.
Viewing rare conformations of the ß2 adrenergic receptor with pressure-resolved DEER spectroscopy.
Proc Natl Acad Sci U S A
; 117(50): 31824-31831, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33257561
8.
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
Nature
; 535(7610): 182-6, 2016 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27362234
9.
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 15(2): 205, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30504785
10.
Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 14(11): 1059-1066, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30327561
11.
Allosteric regulation of G protein-coupled receptor activity by phospholipids.
Nat Chem Biol
; 12(1): 35-9, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26571351
12.
Protonation drives the conformational switch in the multidrug transporter LmrP.
Nat Chem Biol
; 10(2): 149-55, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24316739
13.
Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18.
J Interferon Cytokine Res
; 44(1): 37-42, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37934469
14.
Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
MAbs
; 16(1): 2309685, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38356181
15.
Exposing the molecular heterogeneity of glycosylated biotherapeutics.
Nat Commun
; 15(1): 3259, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38627419
16.
Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution.
ACS Nano
; 18(15): 10464-10484, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38578701
17.
Toxigenic Clostridium perfringens isolated from at-risk pediatric inflammatory bowel disease patients.
J Crohns Colitis
; 2024 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38267224
18.
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
J Med Chem
; 67(6): 4819-4832, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38470227
19.
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun
; 14(1): 7940, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38040762
20.
Structure of the core human NADPH oxidase NOX2.
Nat Commun
; 13(1): 6079, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36241643