Detalhe da pesquisa
1.
Treatment of obesity with celastrol.
Cell
; 161(5): 999-1011, 2015 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26000480
2.
Bright and stable luminescent probes for target engagement profiling in live cells.
Nat Chem Biol
; 17(11): 1168-1177, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675420
3.
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Proc Natl Acad Sci U S A
; 117(16): 8900-8911, 2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32253314
4.
Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-14 C-heptanoyl]-oxy)-benzoic acid methyl ester, [14 C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor.
J Labelled Comp Radiopharm
; 66(7-8): 172-179, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37186406
5.
Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta.
J Org Chem
; 87(2): 1377-1397, 2022 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35014258
6.
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
Bioorg Med Chem
; 42: 116251, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34116381
7.
Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability.
Antimicrob Agents Chemother
; 64(10)2020 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32661007
8.
Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).
Mol Cell Neurosci
; 99: 103386, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31202891
9.
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Proc Natl Acad Sci U S A
; 113(46): 13162-13167, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27799547
10.
A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9.
Angew Chem Int Ed Engl
; 58(19): 6285-6289, 2019 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30834641
11.
Light-controlled modulation of gene expression by chemical optoepigenetic probes.
Nat Chem Biol
; 12(5): 317-23, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26974814
12.
Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks.
Chemistry
; 23(17): 4137-4148, 2017 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27997727
13.
Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained ß-Carboline-Benzoxazepines.
Chemistry
; 23(57): 14182-14192, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28770556
14.
Synthesis and biological evaluation of Santacruzamate-A based analogues.
Bioorg Med Chem
; 25(24): 6486-6491, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29100734
15.
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.
Bioorg Med Chem Lett
; 26(4): 1265-1271, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26804233
16.
Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents.
J Surg Res
; 194(2): 544-550, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25479907
17.
HDAC2 negatively regulates memory formation and synaptic plasticity.
Nature
; 459(7243): 55-60, 2009 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19424149
18.
Chemical interrogation of the malaria kinome.
Chembiochem
; 15(13): 1920-30, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25111632
19.
Monoalkoxy BODIPYs--a fluorophore class for bioimaging.
Bioconjug Chem
; 25(6): 1043-51, 2014 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24797834
20.
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.
Blood
; 119(11): 2579-89, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22262760