Detalhe da pesquisa
1.
A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity.
Chembiochem
; 24(23): e202300351, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37418539
2.
Erratum: iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
iScience
; 27(5): 109727, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38646177
3.
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.
J Med Chem
; 66(4): 2622-2645, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749938
4.
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
J Med Chem
; 66(15): 10617-10627, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467168
5.
iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
iScience
; 26(7): 107059, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37360684
6.
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.
J Med Chem
; 65(12): 8169-8190, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657291
7.
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
Sci Rep
; 12(1): 18633, 2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36329085
8.
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.
J Med Chem
; 64(23): 17079-17097, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34846884
9.
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J Med Chem
; 63(8): 4047-4068, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275432
10.
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
J Med Chem
; 61(3): 918-933, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29240418
11.
Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
Oncotarget
; 6(15): 13019-35, 2015 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25968568
12.
Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
J Biomol Screen
; 18(3): 298-308, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23139381
13.
The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.
Oncotarget
; 4(10): 1647-61, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24072592