Detalhe da pesquisa
1.
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Hum Mol Genet
; 23(11): 2995-3007, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24436303
2.
Animal models of Huntington's disease for translation to the clinic: best practices.
Mov Disord
; 29(11): 1375-90, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25216369
3.
R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures.
J Neurosci
; 32(19): 6456-67, 2012 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22573668
4.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
J Neurosci
; 32(22): 7454-65, 2012 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22649225
5.
Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease.
Neurobiol Dis
; 52: 84-93, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23220414
6.
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Neurobiol Dis
; 35(3): 319-36, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19464370
7.
The Michael J. Fox Foundation for Parkinson's Research Strategy to Advance Therapeutic Development of PINK1 and Parkin.
Biomolecules
; 9(8)2019 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31344817
8.
Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum.
Neuroscience
; 409: 169-179, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31029729
9.
A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein.
J Parkinsons Dis
; 9(1): 31-61, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30400107
10.
Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.
Nat Biotechnol
; 34(8): 838-44, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27376585
11.
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
J Neurosci
; 22(18): 8266-76, 2002 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12223581
12.
Mouse models of Huntington's disease.
Trends Pharmacol Sci
; 23(1): 32-9, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11804649
13.
Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.
J Comp Neurol
; 465(1): 11-26, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12926013
14.
Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.
J Huntingtons Dis
; 3(2): 145-58, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25062858
15.
Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
PLoS One
; 9(6): e99520, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24955833
16.
Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.
PLoS Curr
; 52013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24042107
17.
High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease.
PLoS Curr
; 52013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23863947
18.
Effect of the rd1 mutation on motor performance in R6/2 and wild type mice.
PLoS Curr
; 4: RRN1303, 2012 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22367489
19.
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
PLoS One
; 7(12): e49838, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23284626
20.
Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease.
PLoS Curr
; 3: RRN1225, 2011 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21479110