Detalhe da pesquisa
1.
Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples.
Proc Natl Acad Sci U S A
; 107(50): 21535-40, 2010 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106756
2.
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Eur J Med Chem
; 247: 115022, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36549114
3.
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs.
Nat Commun
; 14(1): 7086, 2023 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37925537
4.
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
Sci Adv
; 9(48): eadh2726, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38019906
5.
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity.
ChemMedChem
; 16(6): 989-999, 2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33220015
6.
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response.
Sci Transl Med
; 13(623): eabf7036, 2021 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34878824
7.
Histone deacetylases and epigenetic therapies of hematological malignancies.
Pharmacol Res
; 62(1): 18-34, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20219679
8.
Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing.
Bioorg Med Chem
; 18(5): 1844-53, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153204
9.
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Mol Autism
; 11(1): 88, 2020 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208191
10.
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Sci Adv
; 6(15): eaax2746, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32284990
11.
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
ChemMedChem
; 15(7): 643-658, 2020 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32003940
12.
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
ACS Med Chem Lett
; 11(5): 754-759, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435381
13.
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
Eur J Med Chem
; 152: 283-297, 2018 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29730191
14.
Cross platform microarray analysis for robust identification of differentially expressed genes.
BMC Bioinformatics
; 8 Suppl 1: S5, 2007 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17430572
15.
Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.
Future Med Chem
; 9(11): 1161-1174, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28722470
16.
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J Med Chem
; 60(5): 1693-1715, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28186757
17.
3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
ACS Med Chem Lett
; 8(5): 521-526, 2017 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28523104
18.
Dual modulation of MCL-1 and mTOR determines the response to sunitinib.
J Clin Invest
; 127(1): 153-168, 2017 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27893461
19.
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
J Med Chem
; 60(5): 1673-1692, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28186755
20.
Compounds and methods for inhibiting histone demethylases: a patent evaluation of US20160102096A1.
Expert Opin Ther Pat
; 26(12): 1367-1370, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27730846