Detalhe da pesquisa
1.
Efficacy and safety of TM5614 in combination with paclitaxel in the treatment of paclitaxel-resistant cutaneous angiosarcoma: Phase II study protocol.
Exp Dermatol
; 33(1): e14976, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37946551
2.
Phase II, multicenter study of plasminogen activator inhibitor-1 inhibitor (TM5614) plus nivolumab for treating anti-PD-1 antibody-refractory malignant melanoma: TM5614-MM trial.
Br J Dermatol
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38833158
3.
Development and Initial Psychometric Validation of the COVID-19 Pandemic Burden Index for Healthcare Workers.
J Gen Intern Med
; 38(5): 1239-1247, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36652099
4.
Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial.
Diabetes Obes Metab
; 25(5): 1280-1291, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36655410
5.
TM5614, an Inhibitor of Plasminogen Activator Inhibitor-1, Exerts an Antitumor Effect on Chronic Myeloid Leukemia.
Tohoku J Exp Med
; 257(3): 211-224, 2022 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35491124
6.
Plasminogen activator inhibitor type-1 is a negative regulator of hematopoietic regeneration in the adipocyte-rich bone marrow microenvironment.
Biochem Biophys Res Commun
; 557: 180-186, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33866038
7.
A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy.
Biochem Biophys Res Commun
; 534: 849-856, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33213843
8.
Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells.
Haematologica
; 106(2): 483-494, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32001531
9.
Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci
; 22(3)2021 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33540702
10.
PAI-1 Regulation of TGF-ß1-induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.
Am J Respir Cell Mol Biol
; 62(3): 319-330, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31513752
11.
Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning.
Biochem Biophys Res Commun
; 516(2): 500-505, 2019 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230745
12.
TGF-ß-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche.
Blood
; 130(21): 2283-2294, 2017 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28821477
13.
Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.
FASEB J
; 31(6): 2625-2637, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28270519
14.
Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives.
Bioorg Med Chem Lett
; 28(4): 809-813, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29366646
15.
Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress.
Psychiatry Clin Neurosci
; 72(1): 35-44, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29064136
16.
Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression.
Int J Mol Sci
; 19(5)2018 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29702605
17.
Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1.
Molecules
; 23(4)2018 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29641495
18.
[Continuation of Axitinib for Advanced Renal Cell Carcinoma by The Application of Homecare Urology - A Case Report and Literature Review].
Gan To Kagaku Ryoho
; 45(4): 639-642, 2018 Apr.
Artigo
em Japonês
| MEDLINE | ID: mdl-29650821
19.
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.
Proc Natl Acad Sci U S A
; 111(19): 7090-5, 2014 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24778222
20.
Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.
J Am Soc Nephrol
; 27(2): 428-38, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26054543