Detalhe da pesquisa
1.
Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.
PLoS Pathog
; 19(1): e1011118, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696458
2.
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.
Annu Rev Microbiol
; 74: 431-454, 2020 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32905757
3.
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
PLoS Pathog
; 18(10): e1010926, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306287
4.
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
J Infect Dis
; 226(11): 2021-2029, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36082431
5.
Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.
Antimicrob Agents Chemother
; 66(1): e0116321, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34694871
6.
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
PLoS Pathog
; 16(4): e1008482, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32310999
7.
Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.
PLoS Pathog
; 14(3): e1006930, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29538461
8.
Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa.
BMC Genomics
; 19(1): 372, 2018 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783949
9.
Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.
PLoS Biol
; 13(4): e1002132, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901609
10.
Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs.
Mol Microbiol
; 91(5): 918-34, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24372851
11.
Transcriptional variation in the malaria parasite Plasmodium falciparum.
Genome Res
; 22(5): 925-38, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22415456
12.
Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum.
PLoS Pathog
; 9(2): e1003170, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23468622
13.
Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures.
Malar J
; 14: 110, 2015 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25880967
14.
A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.
Proc Natl Acad Sci U S A
; 109(26): E1772-81, 2012 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22619330
15.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
bioRxiv
; 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398288
16.
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.
Nat Commun
; 14(1): 3059, 2023 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37244916
17.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Sci Adv
; 9(45): eadi2364, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37939186
18.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Nat Commun
; 14(1): 1455, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36927839
19.
Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.
Lancet Infect Dis
; 22(6): 879-890, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247321
20.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174