Detalhe da pesquisa
1.
An in vitro toolbox to accelerate anti-malarial drug discovery and development.
Malar J
; 19(1): 1, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898492
2.
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proc Natl Acad Sci U S A
; 108(11): 4400-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300861
3.
Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.
Bioorg Med Chem Lett
; 23(2): 455-9, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23245512
4.
3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.
Bioorg Med Chem Lett
; 23(24): 6868-73, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24169234
5.
Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
J Biol Chem
; 286(51): 44035-44044, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22033929
6.
The involvement of a Naâº- and Clâ»-dependent transporter in the brain uptake of amantadine and rimantadine.
Mol Pharm
; 9(4): 883-93, 2012 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352408
7.
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorg Med Chem Lett
; 20(2): 563-6, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962893
8.
Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-ß-cyclodextrin or a co-solvent system.
Biopharm Drug Dispos
; 31(8-9): 450-4, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20865695
9.
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Bioorg Med Chem Lett
; 18(5): 1555-8, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18262417
10.
Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).
J Med Chem
; 60(7): 2654-2668, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28052200
11.
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.
Sci Transl Med
; 9(387)2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446690
12.
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
J Med Chem
; 59(11): 5416-31, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27127993
13.
Discovery and structure-activity relationships of pyrrolone antimalarials.
J Med Chem
; 56(7): 2975-90, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23517371
14.
A prodrug approach toward cancer-related carbonic anhydrase inhibition.
J Med Chem
; 56(23): 9623-34, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24200125
15.
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
J Med Chem
; 56(6): 2547-55, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23489135
16.
In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models.
Drug Des Devel Ther
; 7: 1377-84, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24255594
17.
Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
J Med Chem
; 56(24): 10158-70, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24304150
18.
Probing a potential in vivo drug-excipient interaction: temporal effects of a modified ß-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand.
J Pharm Sci
; 101(9): 3381-9, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22549698
19.
Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII.
J Med Chem
; 55(11): 5506-17, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22540953
20.
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
J Med Chem
; 55(7): 3479-87, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390538