Detalhe da pesquisa
1.
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.
Nature
; 519(7541): 102-5, 2015 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686603
2.
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.
J Biol Chem
; 292(38): 15705-15716, 2017 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28724631
3.
Recent progress on third generation covalent EGFR inhibitors.
Bioorg Med Chem Lett
; 26(8): 1861-8, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26968253
4.
An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations.
Anal Biochem
; 484: 82-90, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25433146
5.
Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.
Bioorg Med Chem Lett
; 24(17): 4187-91, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25091930
6.
A simple and efficient maleimide-based approach for peptide extension with a cysteine-containing peptide phage library.
Bioorg Med Chem Lett
; 23(20): 5680-3, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23992863
7.
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Proc Natl Acad Sci U S A
; 107(20): 9446-51, 2010 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20439741
8.
Protein kinase biochemistry and drug discovery.
Bioorg Chem
; 39(5-6): 192-210, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21872901
9.
Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.
Mol Cancer Ther
; 20(12): 2446-2456, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625502
10.
TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations.
Mol Cancer Ther
; 20(9): 1499-1507, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34158340
11.
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
J Med Chem
; 64(13): 9056-9077, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110834
12.
Structure-based design of novel human Pin1 inhibitors (II).
Bioorg Med Chem Lett
; 20(7): 2210-4, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207139
13.
Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling.
Cell Rep
; 30(6): 1935-1950.e8, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049022
14.
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
J Med Chem
; 63(21): 12725-12747, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33054210
15.
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.
Biochemistry
; 48(23): 5339-49, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19459657
16.
Characterizing the effects of the juxtamembrane domain on vascular endothelial growth factor receptor-2 enzymatic activity, autophosphorylation, and inhibition by axitinib.
Biochemistry
; 48(29): 7019-31, 2009 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19526984
17.
Structure-based design of novel human Pin1 inhibitors (I).
Bioorg Med Chem Lett
; 19(19): 5613-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19729306
18.
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.
Clin Cancer Res
; 14(22): 7272-83, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19010843
19.
Analysis of Cysteine Redox Post-Translational Modifications in Cell Biology and Drug Pharmacology.
Methods Mol Biol
; 1558: 191-212, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28150239
20.
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
J Med Chem
; 60(23): 9617-9629, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29111717