Detalhe da pesquisa
1.
Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34 antagonists.
Bioorg Med Chem Lett
; 97: 129548, 2024 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37949379
2.
Discovery of thieno[2,3-d]pyrimidin-4(3H)-one derivatives as a new class of ROCK inhibitors.
Bioorg Med Chem Lett
; 30(6): 126966, 2020 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32001136
3.
Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations.
Bioorg Med Chem Lett
; 30(22): 127532, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32891702
4.
Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway.
Int Immunopharmacol
; 127: 111314, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38081102
5.
Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model.
Invest Ophthalmol Vis Sci
; 64(1): 1, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36595275
6.
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain.
J Med Chem
; 66(5): 3460-3483, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36821347
7.
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants.
Signal Transduct Target Ther
; 8(1): 128, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36928316
8.
Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo.
Eur J Med Chem
; 232: 114187, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35183872
9.
Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.
Eur J Med Chem
; 232: 114194, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35183871
10.
Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants.
J Med Chem
; 65(3): 2035-2058, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35080890
11.
Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).
Eur J Med Chem
; 207: 112703, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32871341