Detalhe da pesquisa
1.
Mechanism of a Standalone ß-Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme.
Chembiochem
; 20(13): 1701-1711, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30856684
2.
Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 60(11): 6451-6459, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527085
3.
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Nat Chem Biol
; 10(2): 96-8, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24292073
4.
The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 59(8): 4446-52, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987616
5.
Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-ß-D-ribose 2'-oxidase.
Bioorg Med Chem
; 23(24): 7694-710, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26643218
6.
Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy.
Mol Neurobiol
; 61(4): 2367-2389, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874479
7.
Insights into the activity and specificity of Trypanosoma cruzi trans-sialidase from molecular dynamics simulations.
Biochemistry
; 52(21): 3740-51, 2013 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23672572
8.
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.
Mol Microbiol
; 77(5): 1172-85, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20624223
9.
Tryptophan as a molecular shovel in the glycosyl transfer activity of Trypanosoma cruzi trans-sialidase.
Biophys J
; 98(9): L38-40, 2010 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20441732
10.
Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis.
Biochemistry
; 49(43): 9292-305, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20853905
11.
Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Biochemistry
; 49(8): 1689-701, 2010 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20099905
12.
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.
Bioorg Med Chem Lett
; 19(3): 589-96, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144516
13.
Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.
Biochemistry
; 47(45): 11735-49, 2008 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18928302
14.
Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease.
Drug Discov Today
; 13(3-4): 110-7, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18275908
15.
Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria.
ACS Chem Biol
; 13(11): 3184-3192, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30289689
16.
Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity.
ChemMedChem
; 11(3): 331-9, 2016 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751718
17.
Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.
J Med Chem
; 48(15): 4861-70, 2005 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16033266
18.
DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization.
ACS Chem Biol
; 10(7): 1631-6, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25906160
19.
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.
ACS Chem Biol
; 10(3): 705-14, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25427196
20.
The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum.
Chembiochem
; 10(17): 2730-2, 2009 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19830761